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791342

Sigma-Aldrich

Silica, nanoparticle dispersion in water

<50 nm (DLS), triethoxylpropylaminosilane functionalized

Synonym(s):

NH2 functionalized NPs

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About This Item

UNSPSC Code:
12352302
NACRES:
NA.23

Quality Level

form

dispersion
nanoparticles

shelf life

1 yr

concentration

in water (Dispersion)

particle size

<50 nm (DLS)

functional group

amine

storage temp.

20-25°C

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General description

Composition of nanoparticles non-crystalline colloidal SiO2 particles
Dispersion loading and medium (27 ± 3) wt.-% in water
Particle size d90 (volume distribution; DLS) < 50 nm
pH 2 ± 1
Density (1.2 ± 0.1) g/l
Primary particle size < 20 nm
Surface modification using Triethoxylpropylaminosilane

Application

Silica nanoparticles play a crucial role in biotechnology including bone engineering and drug delivery. The amino functionality present on the surface of these materials provide a synthetic handle for further modification and conjugation to target moieties. Amino functionalized silica particles can be used for applicaitons including in vivo gene delivery, nanocomposite formation, and formation of biofilms.

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CorrosionExclamation mark

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Danger

hcodes

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Kazuki Murai et al.
Physical chemistry chemical physics : PCCP, 15(27), 11454-11460 (2013-06-12)
We investigated the drug releasing behavior of a novel nanocarrier system, utilizing a peptide to act as a nanogate to the mesopore, on a mesoporous silica nanoparticle. The surface peptide on mesoporous silica displayed pH-dependant mesopore cap-uncap switching behavior, enabled
Dhruba J Bharali et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(32), 11539-11544 (2005-07-30)
This article reports on the application of organically modified silica (ORMOSIL) nanoparticles as a nonviral vector for efficient in vivo gene delivery. Highly monodispersed, stable aqueous suspension of nanoparticles, surface-functionalized with amino groups for binding of DNA, were prepared and
Preparation and characterization of epoxy composites filled with functionalized nanosilica particles obtained via sol-gel process
Kang, S..;
Polymer, 42(3), 879-887 (2000)
Pingli He et al.
Langmuir : the ACS journal of surfaces and colloids, 20(3), 722-729 (2005-03-19)
Heme protein hemoglobin (Hb) or myoglobin (Mb) and silica nanoparticles in a variety of charge states were assembled layer-by-layer into films on solid surfaces to investigate the driving forces for film assembly. Cyclic voltammetry (CV), quartz crystal microbalance (QCM), X-ray
Indrajit Roy et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(2), 279-284 (2005-01-05)
This article reports a multidisciplinary approach to produce fluorescently labeled organically modified silica nanoparticles as a nonviral vector for gene delivery and biophotonics methods to optically monitor intracellular trafficking and gene transfection. Highly monodispersed, stable aqueous suspensions of organically modified

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