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MilliporeSigma

792632

Isoflurane

Synonym(s):

Isoflurane, 1-Chloro-1-(difluoromethoxy)-2,2,2-trifluoroethane, 1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether

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250 MG

$48.80

1 G

$132.00

$48.80


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About This Item

Empirical Formula (Hill Notation):
C3H2ClF5O
CAS Number:
Molecular Weight:
184.49
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

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vapor pressure

238 mmHg ( 20 °C)

form

liquid

refractive index

n20/D 1.302

bp

48.5 °C

density

1.510 g/mL at 25 °C

functional group

chloro
ether
fluoro

storage temp.

2-8°C

SMILES string

FC(F)OC(Cl)C(F)(F)F

InChI

1S/C3H2ClF5O/c4-1(3(7,8)9)10-2(5)6/h1-2H

InChI key

PIWKPBJCKXDKJR-UHFFFAOYSA-N

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1 of 4

This Item
Y0000858PHR28741349003
form

liquid

form

-

form

-

form

-

Quality Level

100

Quality Level

-

Quality Level

300

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-30°C

storage temp.

-

vapor pressure

238 mmHg ( 20 °C)

vapor pressure

-

vapor pressure

-

vapor pressure

-

refractive index

n20/D 1.302

refractive index

-

refractive index

-

refractive index

-

bp

48.5 °C

bp

-

bp

-

bp

-

General description

Isofluraneis a fluorinated methyl ether and isomer of enflurane. The Federal DrugAdministration (FDA) has approved it for use as a volatile anesthetic to induceand maintain general anesthesia.

Application

Isoflurane is a volatile anesthetic agent mainly used to study its interaction with the biological system.[1][2]

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

STOT SE 3

target_organs

Central nervous system

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Satya Prathyusha Bhamidimarri et al.
Structure (London, England : 1993), 27(2), 268-280 (2018-12-18)
Research efforts to discover potential new antibiotics for Gram-negative bacteria suffer from high attrition rates due to the synergistic action of efflux systems and the limited permeability of the outer membrane (OM). One strategy to overcome the OM permeability barrier
Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain.
Brambrink AM, et al.
Anesthesiology, 112(4), 834-841 (2010)
Wenjuan Sun et al.
Frontiers in pharmacology, 12, 708575-708575 (2021-10-01)
Maslinic acid (MA), also named crategolic acid, is a pentacyclic triterpene extracted from fruits and vegetables. Although various beneficial pharmacological effects of MA have been revealed, its effect on renal fibrosis remains unclear. This study was designed to clarify whether
Hao Zhang et al.
Molecular medicine reports, 22(2), 915-925 (2020-07-07)
Dilated cardiomyopathy (DCM) is a primary cardiomyopathy with high mortality. The aim of the present study was to identify the related genes in DCM. The four expression profiles (GSE17800, GSE21610, GSE42955 and GSE79962) downloaded from the Gene Expression Omnibus (GEO)
Sherrefa R Burchell et al.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 61(7), 1078-1083 (2013-07-26)
Isoflurane is a volatile anesthetic that is widely used clinically as an inhalational anesthetic. In recent years, several studies have indicated that isoflurane has neuroprotective properties. This has led to the beneficial effects of isoflurane being analyzed in both cell

Questions

1–4 of 4 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. We need this in liquid form for anaesthetized the mice. But this is showing in mg, is it available in liquid.

    1 answer
    1. This product is a neat or pure liquid with a density of 1.51 g/mL. The purity of this material is reported in the product Certificate of Analysis and may range from 84.5% - 100%. The molarity may be calculated based on the lot specific purity. At the minimum purity of 84.5%, the molarity is 6.95 and at the maximum 100% purity, the molarity is 8.18. Please see the link below to review a sample or lot specific Certificate of Analysis:
      https://www.sigmaaldrich.com/product/aldrich/792632#product-documentation

      Helpful?

  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  4. マウス実験に用いたいのですが、溶解法を教えてください 250mgを購入させてもらいました。

    1 answer
    1. Isoflurane may be dissolved in a 1:1 solution of DMSO:PBS (pH 7.2). For use as an anesthetic in mouse models, the link below offers an alternative solvent of propylene glycol:
      https://www.research.uky.edu/division-laboratory-animal-resources/open-drop-or-nose-cone-method-isoflurane-anesthesia-mice-and#:~:text=The%20open%2Ddrop%20method%20of,syringe%20with%20the%20plunger%20removed.

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