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861545

Sigma-Aldrich

N10-(Trifluoroacetyl)pteroic acid

95%

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Synonym(s):
4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl](2,2,2-trifluoroacetyl)amino]benzoic acid, N10-Trifluoroacetylpteroic acid
Empirical Formula (Hill Notation):
C16H11F3N6O4
CAS Number:
Molecular Weight:
408.29
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

95%

form

solid

mp

270 °C (dec.) (lit.)

SMILES string

Nc1nc(O)c2nc(CN(c3ccc(cc3)C(O)=O)C(=O)C(F)(F)F)cnc2n1

InChI

1S/C16H11F3N6O4/c17-16(18,19)14(29)25(9-3-1-7(2-4-9)13(27)28)6-8-5-21-11-10(22-8)12(26)24-15(20)23-11/h1-5H,6H2,(H,27,28)(H3,20,21,23,24,26)

InChI key

IJGIHDXKYQLIMA-UHFFFAOYSA-N

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This Item
P1781M3884794260
vibrant-m

861545

N10-(Trifluoroacetyl)pteroic acid

vibrant-m

P1781

Pteroic acid

vibrant-m

794260

10-Phenyl-9(10H)-acridinone

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

form

solid

form

powder

form

-

form

solid

mp

270 °C (dec.) (lit.)

mp

-

mp

-

mp

274-279 °C

Application

N10-(Trifluoroacetyl)pteroic acid is a structural component of folic acid. It can be used as a precursor to synthesize folic acid derivatives, γ-azido modified folic acid, and pteroyl-γ-glutamate-cysteine.

Other Notes

Remainder DMF

pictograms

Exclamation markHealth hazard

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


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The cell membrane folate receptor is a potential molecular target for tumor-selective drug delivery. To probe structural requirements for folate receptor targeting with low molecular weight radiometal chelates, specifically the role of the amino acid fragment of folic acid (pteroylglutamic

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