900475

Sigma-Aldrich

Gold nanoparticles

20 nm, NHS ester functionalized, conjugation kit

Synonym(s):
NHS-activated gold nanoparticles
NACRES:
NA.23

form

nanoparticles

shelf life

12 mo. at -20 °C (If stored unopened and as specified, are stable for at least 12 months)

packaging

pkg of 1 ea

storage condition

protect from light

particle size

20 nm

λmax

524 nm

functional group

NHS ester

storage temp.

−20°C

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Application

NHS ester functionalized gold nanoparticle conjugation kit (20 nm) can be used in the surface modification of indium tin oxide (ITO) electrodes for potential usage in electrocatalysis, and electrochemical sensing.
AuNPs may be used to prepare SARS-CoV-2 conjugate for COVID-19 detection using lateral flow immunoassay technique. It can be potentially used in immobilization of antibodies to improve the sensitivity of optical fiber sensors for the screening of COVID-19. It can also be deposited on the titanium electrode for the formation of a miniaturized device for the electrochemical detection of DNA hybridization.

Legal Information

Product of CytoDiagnostics, Inc.

RIDADR

NONH for all modes of transport

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Facile modification of ITO electrodes with functional materials through catalytic grafting of N-hydroxysuccinimidyl-ester-functionalized methallylsilane
Kumar SS, et al.
Electrochemical Communications, 19, 123-126 (2012)
Optical Fiber Sensors for Rapid Screening of COVID-19
Nag P, et al.
Transactions of the Indian National Academy of Engineering, 143(9), 1-4 (2020)
Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis
Li Z, et al.
Journal of Medical Virology, 78, 396-403 (2020)
Immobilization strategy for enhancing sensitivity of immunosensors: L-Asparagine-AuNPs as a promising alternative of EDC-NHS activated citrate-AuNPs for antibody immobilization
Raghav R and Srivastava S
Biosensors And Bioelectronics, 78, 396-403 (2016)
Recent advances in nanoparticle-based lateral flow immunoassay as a point-of-care diagnostic tool for infectious agents and diseases
Banerjee R and Jaiswal A
Analyst, 143(9), 1970-1996 (2018)
Articles
The CRISPR/Cas9 system has recently emerged as a highly specific, efficient, and versatile gene editing technology that can be utilized to build disease models and correct diseased genes. Safe and effective delivery vectors for the CRISPR/Cas9 system are in critical need to enable clinical development and future applications of CRISPR/Cas9 systems. Professor Yang Liu summarizes recent progress in nonviral nanoparticle approaches for CRISPR/Cas9 delivery.
Read More
Drs. Fernandes and Baptista explore the synthesis and functionalization of gold nanoparticles and their use in molecular diagnostics, focusing on lateral flow assays. They further discuss the regulations and standards of these materials, as well as the future outlook and challenges.
Read More

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