900477

Sigma-Aldrich

Gold nanoparticles

40 nm, NHS ester functionalized, conjugation kit

Synonym(s):
NHS-activated gold nanoparticles
NACRES:
NA.23

form

nanoparticles

shelf life

12 mo. at -20 °C (If stored unopened and as specified, are stable for at least 12 months)

packaging

pkg of 1 ea

storage condition

protect from light

particle size

40 nm

λmax

530 nm

functional group

NHS ester

storage temp.

−20°C

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Application

NHS ester functionalized gold nanoparticles conjugation kit (40 nm) can be used in the surface modification of indium tin oxide (ITO) electrodes for potential usage in electrocatalysis, and electrochemical sensing.
AuNPs may be used to prepare SARS-CoV-2 conjugate for COVID-19 detection using lateral flow immunoassay technique. It can be potentially used in immobilization of antibodies to improve the sensitivity of optical fiber sensors for the screening of COVID-19. It can also be deposited on the titanium electrode for the formation of a miniaturized device for the electrochemical detection of DNA hybridization.

Legal Information

Product of CytoDiagnostics, Inc.

RIDADR

NONH for all modes of transport

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Jin-Hee Han et al.
Journal of pharmaceutical and biomedical analysis, 181, 113101-113101 (2020-01-27)
We evaluated the use of gold nanoparticles (AuNPs) platform in a homogenous assay for a potency measurement of a therapeutic monoclonal antibody (mAb). The recombinant human ligand protein to the therapeutic mAb was immobilized on AuNPs via functionalized self-assembled monolayers....
Facile modification of ITO electrodes with functional materials through catalytic grafting of N-hydroxysuccinimidyl-ester-functionalized methallylsilane
Kumar SS, et al.
Electrochemical Communications, 19, 123-126 (2012)
Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis
Li Z, et al.
Journal of Medical Virology, 78, 396-403 (2020)
Immobilization strategy for enhancing sensitivity of immunosensors: L-Asparagine-AuNPs as a promising alternative of EDC-NHS activated citrate-AuNPs for antibody immobilization
Raghav R and Srivastava S
Biosensors And Bioelectronics, 78, 396-403 (2016)
Optical Fiber Sensors for Rapid Screening of COVID-19
Nag P, et al.
Transactions of the Indian National Academy of Engineering, 143(9), 1-4 (2020)
Articles
Drs. Fernandes and Baptista explore the synthesis and functionalization of gold nanoparticles and their use in molecular diagnostics, focusing on lateral flow assays. They further discuss the regulations and standards of these materials, as well as the future outlook and challenges.
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