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900913

Sigma-Aldrich

Tetrazine-PEG5-NHS ester

≥95%

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Synonym(s):
Tz-PEG5-NHS
Empirical Formula (Hill Notation):
C27H36N6O10
CAS Number:
1682653-80-0
Molecular Weight:
604.61
MDL number:
MFCD28505547
NACRES:
NA.22

Quality Level

100

Assay

≥95%

form

powder or crystals

reaction suitability

reaction type: click chemistry
reagent type: linker

functional group

NHS ester

storage temp.

−20°C

SMILES string

O=C(NCC1=CC=C(C2=NN=CN=N2)C=C1)CCOCCOCCOCCOCCOCCC(ON3C(CCC3=O)=O)=O

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This Item
764191803537761591
Tetrazine-PEG5-NHS ester ≥95%

Sigma-Aldrich

900913

Tetrazine-PEG5-NHS ester

Alkyne-PEG5-N-hydroxysuccinimidyl ester

Sigma-Aldrich

764191

Alkyne-PEG5-N-hydroxysuccinimidyl ester

Bis(NHS)PEG5

Sigma-Aldrich

803537

Bis(NHS)PEG5

(4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine hydrochloride 95%

Sigma-Aldrich

761591

(4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine hydrochloride

form

powder or crystals

form

liquid

form

liquid

form

solid

reaction suitability

reaction type: click chemistry, reagent type: linker

reaction suitability

reaction type: click chemistry, reagent type: cross-linking reagent

reaction suitability

-

reaction suitability

reaction type: click chemistry, reagent type: linker

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

functional group

NHS ester

functional group

NHS ester, alkyne

functional group

-

functional group

amine

General description

Tetrazine-PEG5-NHS ester has an N-hydroxysuccinimide (NHS) ester that can be reacted with primary amines and tetrazine, which is reactive to trans-cyclooctenes. Hydrogen substituted tetrazines demonstrate exceptionally fast kinetics, generally at least 10-fold faster compared to methyl substituted tetrazines. The aqueous solubility of this reagent is substantially enhanced by a hydrophilic polyethylene glycol (PEG) spacer arm.

Application

Tetrazine-PEG5-NHS ester (Tz-PEG5-NHS) can be used in click chemistry applications such as the preparation of chitosan-polyacrylamide microspheres utilizing selective tetrazine-trans-cyclooctene (Tz-TCO) ligation and the construction of copper-64 radiolabeled antibody by the click reaction.

related product

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Shape-Encoded Chitosan?Polyacrylamide Hybrid Hydrogel Microparticles with Controlled Macroporous Structures via Replica Molding for Programmable Biomacromolecular Conjugation.
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Porosity-Tuned Chitosan?Polyacrylamide Hydrogel Microspheres for Improved Protein Conjugation.
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