901565
Propargyl-PEG3-acid
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| Size/SKU | Availability | Price |
|---|---|---|
50 mg | Available to ship TODAYfromMILWAUKEE | $167.00 $125.25 |
About This Item
Empirical Formula (Hill Notation):
C10H16O5
CAS Number:
Molecular Weight:
216.23
UNSPSC Code:
12352106
NACRES:
NA.22
MDL number:
$125.25
List Price$167.00Save 25%Web-Only Promotion
Available to ship TODAYDetails
form
liquid
reaction suitability
reagent type: linker
functional group
alkyne, carboxylic acid
storage temp.
−20°C
SMILES string
C#CCOCCOCCOCCC(O)=O
InChI key
CJNSWLAJTZVSRB-UHFFFAOYSA-N
Application
Propargyl-PEG3-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG3-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.
This is a crosslinker with an alkyne group on one end and a carboxyl group on the other end. The alkyne can be used to attach to an azide using copper-catalyzed click chemistry. The compound contains three PEG units to help improve solubility.
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
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This Item | |||
|---|---|---|---|
| reaction suitability reagent type: linker | reaction suitability reagent type: linker | reaction suitability - | reaction suitability reagent type: linker |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| functional group alkyne, carboxylic acid | functional group alkyne, carboxylic acid | functional group alkyne, carboxylic acid | functional group alkyne, carboxylic acid |
| form liquid | form liquid | form liquid | form liquid |
Storage Class
10 - Combustible liquids
wgk
WGK 3
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