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MilliporeSigma

901594

Diisopropylcarbodiimide solution

1 M in THF

Synonym(s):

Diisopropylmethanediimine

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25 ML

$106.50

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$274.00

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About This Item

Linear Formula:
C7H14N2
CAS Number:
UNSPSC Code:
12352111
NACRES:
NA.22
MDL number:

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SMILES string

N(=C=NC(C)C)C(C)C

InChI

1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3

InChI key

BDNKZNFMNDZQMI-UHFFFAOYSA-N

form

liquid

reaction suitability

reaction type: Coupling Reactions

concentration

1 M in THF

density

0.870 g/mL

application(s)

peptide synthesis

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This Item
G152247608680303
form

liquid

form

liquid

form

liquid

form

liquid

reaction suitability

reaction type: Coupling Reactions

reaction suitability

-

reaction suitability

-

reaction suitability

-

concentration

1 M in THF

concentration

50 mg/mL gentamicin

concentration

≥36.0% in H2O (T), 36.0-38.0% (aldehyde method)

concentration

-

density

0.870 g/mL

density

1.000 g/cm3

density

1.09 g/mL at 20 °C, 1.09 g/mL at 25 °C (lit.)

density

0.914 g/mL at 25 °C

application(s)

peptide synthesis

application(s)

-

application(s)

-

application(s)

-

Application

Coupling reagent for peptide syntheses.[1][2][3]
DIC (N,N′-Diisopropylcarbodiimide) has been used in combination with 1-hydroxy-7-azabenzotriazole (HOAt) for the coupling of amino acid with N-allylglycine to form N-allylpeptide.[4]
Valuable reagent offered as a solution in tetrahydrofuran for more convenient handling.

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signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Resp. Sens. 1 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

supp_hazards

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

2.0 °F

flash_point_c

-16.66 °C


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Stéphane Chantepie et al.
PloS one, 10(7), e0133140-e0133140 (2015-07-29)
Do all traits within an organism age for the same reason? Evolutionary theories of aging share a common assumption: the strength of natural selection declines with age. A corollary is that additive genetic variance should increase with age. However, not
Tetrahedron Letters, 35, 5981-5981 (1994)
Collection of Czechoslovak Chemical Communications, 59, 691-691 (1994)
Cody L Gilleland et al.
Genetics, 201(1), 39-46 (2015-07-15)
A major goal in the study of human diseases is to assign functions to genes or genetic variants. The model organism Caenorhabditis elegans provides a powerful tool because homologs of many human genes are identifiable, and large collections of genetic
P J Weber et al.
Bioorganic & medicinal chemistry letters, 8(6), 597-600 (1999-01-01)
A new method has been developed to synthesize fluorescein labeled peptides, compounds of increasing importance in bioorganic chemistry, cell biology, pharmacology, drug targeting and medicinal chemistry. We show, that 4(5)-carboxyfluorescein is much more efficient than the hitherto predominantly utilized reagents

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