901743
Poly(OEGMA)
aldehyde functionalized, 25 wt% solution in water
Synonym(s):
PEGMA, POEGMA
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About This Item
Linear Formula:
[CH2CCH3(COO(CH2CH2O)8CH3)]m[CH2CCH3(CONHCH2COH)]q
UNSPSC Code:
12162002
NACRES:
NA.23
Recommended Products
form
solution
mol wt
~20,000 g/mol
color
clear colorless to pale yellow
storage temp.
2-8°C
General description
Poly(oligoethylene glycol methacrylate) (POEGMA), is a comb-shaped, graft copolymer consisting of hydrophilic oligomer PEG chains grafted to a hydrophobic polymethacrylate backbone. POEGMA has been suggested as a viable alternative to poly(ethylene glycol) (PEG) in biological and biomaterial applications. POEGMA has been reported to improve pharmacokinetic properties of protein and peptide conjugates[1][2], enhance the stability and gene silencing efficiency of siRNAs[3], as an anti-fouling surface for biosensors[4], and eliminate PEG antigenicity[5][6]. In addition to use in biomolecule-polymer conjugates, PEOGMA has also seen wide spread use in tissue engineering applications, such as hydrogel synthesis. Aldehyde-functionalized POEGMA can be readily used with the corresponding hydrazide-functionalized POEGMA for rapid gelation via reversible hydrazone bond formation[7]. Due to the reversibility of the bond formation and the low viscosity of the precursors, resulting hydrogels can be used as injectable tissue engineering matrices, local drug delivery vehicles for small molecules, or as joint lubricants[8][9]. In addition, the physical properties of the resulting hydrogels, such as LCST, gelation rates, swelling kinetics, degredation kinetics, and mechanical properties, can all be readily controlled by solution concentration and the ratios of each solution[10][11].
Preparation Note
This product is provided as a 25 wt% solution in water, ready to be diluted for your specific application. Please see the technical bulletin on the product page for dilution and hydrogel preparation instructions.
Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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A brush-polymer/exendin-4 conjugate reduces blood glucose levels for up to five days and eliminates poly(ethylene glycol) antigenicity.
Qi Y, et al.
Nature Biomedical Engineering, 1, 2-2 (2016)
Imran Ozer et al.
Biomacromolecules, 18(9), 2699-2710 (2017-08-05)
PEGylation, covalent attachment of PEG to therapeutic biomolecules, in which suboptimal pharmacokinetic profiles limiting their therapeutic utility are of concern, is a widely applied technology. However, this technology has been challenged by reduced bioactivity of biomolecules upon PEGylation and immunogenicity
Niels M B Smeets et al.
Chemical communications (Cambridge, England), 50(25), 3306-3309 (2014-02-18)
Injectable PEG-analogue hydrogels based on poly(oligoethylene glycol methacrylate) have been developed based on complementary hydrazide and aldehyde reactive linear polymer precursors. These hydrogels display the desired biological properties of PEG, form covalent networks in situ following injection, and are easily
Weiping Gao et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(36), 15231-15236 (2009-08-27)
The challenge in the synthesis of protein-polymer conjugates for biological applications is to synthesize a stoichiometric (typically 1:1) conjugate of the protein with a monodisperse polymer, with good retention of protein activity, significantly improved pharmacokinetics and increased bioavailability, and hence
?Off-the-shelf? thermoresponsive hydrogel design: tuning hydrogel properties by mixing precursor polymers with different lower-critical solution temperatures.
Bakaic E, et al.
Royal Society of Chemistry Advances, 5, 33364-33376 (2015)
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