MilliporeSigma
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901743

Sigma-Aldrich

Poly(OEGMA)

aldehyde functionalized, 25 wt% solution in water

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Synonym(s):
PEGMA, POEGMA
Linear Formula:
[CH2CCH3(COO(CH2CH2O)8CH3)]m[CH2CCH3(CONHCH2COH)]q
NACRES:
NA.23

form

solution

mol wt

~20,000 g/mol

color

clear colorless to pale yellow

storage temp.

2-8°C

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This Item
9017761010862600110223581001
Poly(OEGMA) aldehyde functionalized, 25 wt% solution in water

Sigma-Aldrich

901743

Poly(OEGMA)

Poly(OEGMA) hydrazide functionalized, 25 wt% solution in water

Sigma-Aldrich

901776

Poly(OEGMA)

Poly(A) lyophilized, suitable for PCR, pkg of 100 mg

Roche

10108626001

Poly(A)

Poly(dA) Poly-deoxy-adenylic acid

Roche

10223581001

Poly(dA)

form

solution

form

solution

form

lyophilized

form

lyophilized

mol wt

~20,000 g/mol

mol wt

~20,000 g/mol

mol wt

700-3500 kDa

mol wt

330 Da

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C (−15°C to −25°C)

color

clear colorless to pale yellow

color

clear colorless to pale yellow

color

-

color

-

General description

Poly(oligoethylene glycol methacrylate) (POEGMA), is a comb-shaped, graft copolymer consisting of hydrophilic oligomer PEG chains grafted to a hydrophobic polymethacrylate backbone. POEGMA has been suggested as a viable alternative to poly(ethylene glycol) (PEG) in biological and biomaterial applications. POEGMA has been reported to improve pharmacokinetic properties of protein and peptide conjugates, enhance the stability and gene silencing efficiency of siRNAs, as an anti-fouling surface for biosensors, and eliminate PEG antigenicity. In addition to use in biomolecule-polymer conjugates, PEOGMA has also seen wide spread use in tissue engineering applications, such as hydrogel synthesis. Aldehyde-functionalized POEGMA can be readily used with the corresponding hydrazide-functionalized POEGMA for rapid gelation via reversible hydrazone bond formation. Due to the reversibility of the bond formation and the low viscosity of the precursors, resulting hydrogels can be used as injectable tissue engineering matrices, local drug delivery vehicles for small molecules, or as joint lubricants. In addition, the physical properties of the resulting hydrogels, such as LCST, gelation rates, swelling kinetics, degredation kinetics, and mechanical properties, can all be readily controlled by solution concentration and the ratios of each solution.

Preparation Note

This product is provided as a 25 wt% solution in water, ready to be diluted for your specific application. Please see the technical bulletin on the product page for dilution and hydrogel preparation instructions.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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