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901776

Sigma-Aldrich

Poly(OEGMA)

hydrazide functionalized, 25 wt% solution in water

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Synonym(s):
PEGMA, POEGMA
Linear Formula:
[CH2CCH3(COO(CH2CH2O)8CH3)]m[CH2CHCONHNHCO(CH2)4CONHNH2]p
NACRES:
NA.23

form

solution

mol wt

~20,000 g/mol

color

clear colorless to pale yellow

functional group

hydrazide

storage temp.

2-8°C

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This Item
901777901546P2139
Poly(OEGMA) hydrazide functionalized, 25 wt% solution in water

Sigma-Aldrich

901776

Poly(OEGMA)

Poly(ethylene glycol) average mol wt 8,000, powder

Sigma-Aldrich

P2139

Poly(ethylene glycol)

mol wt

~20,000 g/mol

mol wt

-

mol wt

Mw ~20,000 g/mol

mol wt

average mol wt 8,000

functional group

hydrazide

functional group

-

functional group

hydrazide

functional group

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

color

clear colorless to pale yellow

color

clear colorless to pale yellow

color

clear colorless to pale yellow

color

-

General description

Poly(oligoethylene glycol methacrylate) (POEGMA), is a comb-shaped, graft copolymer consisting of hydrophilic oligomer PEG chains grafted to a hydrophobic polymethacrylate backbone. POEGMA has been suggested as a viable alternative to poly (ethylene glycol) (PEG) in biological and biomaterial applications. POEGMA has been reported to improve pharmacokinetic properties of protein and peptide conjugates, enhance the stability and gene silencing efficiency of siRNAs, as an anti-fouling surface for biosensors, and eliminate PEG antigenicity. In addition to use in biomolecule-polymer conjugates, PEOGMA has also seen wide spread use in tissue engineering applications, such as hydrogel synthesis. Hydrazide-functionalized POEGMA can be readily used with the corresponding aldehyde-functionalized POEGMA for rapid gelation via reversible hydrazone bond formation. Due to the reversibility of the bond formation and the low viscosity of the precursors, resulting hydrogels can be used as injectable tissue engineering matrices, local drug delivery vehicles for small molecules, or as joint lubricants. In addition, the physical properties of the resulting hydrogels, such as LCST, gelation rates, swelling kinetics, degradation kinetics, and mechanical properties, can all be readily controlled by solution concentration and the ratios of each solution.

Preparation Note

This product is provided as a 25 wt% solution in water, ready to be diluted for your specific application. Please see the technical bulletin on the product page for dilution and hydrogel preparation instructions.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Reactive electro spinning of degradable poly(oligoethylene glycol methacrylate)-based nanofibrous hydrogel networks.
Xu F, et al.
Chemical Communications (Cambridge, England), 52, 1451-1454 (2016)
A brush-polymer/exendin-4 conjugate reduces blood glucose levels for up to five days and eliminates poly(ethylene glycol) antigenicity.
Qi Y, et al.
Nature Biomedical Engineering, 1, 2-2 (2016)
Weiping Gao et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(36), 15231-15236 (2009-08-27)
The challenge in the synthesis of protein-polymer conjugates for biological applications is to synthesize a stoichiometric (typically 1:1) conjugate of the protein with a monodisperse polymer, with good retention of protein activity, significantly improved pharmacokinetics and increased bioavailability, and hence
Imran Ozer et al.
Biomacromolecules, 18(9), 2699-2710 (2017-08-05)
PEGylation, covalent attachment of PEG to therapeutic biomolecules, in which suboptimal pharmacokinetic profiles limiting their therapeutic utility are of concern, is a widely applied technology. However, this technology has been challenged by reduced bioactivity of biomolecules upon PEGylation and immunogenicity
?Off-the-shelf? thermoresponsive hydrogel design: tuning hydrogel properties by mixing precursor polymers with different lower-critical solution temperatures.
Bakaic E, et al.
Royal Society of Chemistry Advances, 5, 33364-33376 (2015)

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