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901777

Sigma-Aldrich

Poly(M(EO)2MA:Poly(OEGMA)

(90:10), aldehyde functionalized, 25 wt% solution in water

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Synonym(s):
PEGMA-co-POEGMA
Linear Formula:
[CH2CCH3(COO(CH2CH2O)2CH3)]n[CH2CCH3(COO(CH2CH2O)8CH3)]m[CH2CCH3(CONHCH2COH)]q
NACRES:
NA.23

form

solution

feed ratio

(90:10)

color

clear colorless to pale yellow

storage temp.

2-8°C

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901546901023901020
Poly(M(EO)2MA:Poly(OEGMA) (90:10), aldehyde functionalized, 25 wt% solution in water

Sigma-Aldrich

901777

Poly(M(EO)2MA:Poly(OEGMA)

Poly(M(EO)2MA:Poly(OEGMA) 90:10 hydrazide functionalized, 25 wt. % (solution in water)

Sigma-Aldrich

901546

Poly(M(EO)2MA:Poly(OEGMA) 90:10

Poly(L-lactide-co-D,L-lactide) 70:30, viscosity 2.5 dL/g 

Sigma-Aldrich

901023

Poly(L-lactide-co-D,L-lactide)

Poly(dioxanone-co-glycolide) 90:10, viscosity 2.0 dL/g 

Sigma-Aldrich

901020

Poly(dioxanone-co-glycolide)

form

solution

form

solution

form

chips

form

chips

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

feed ratio

(90:10)

feed ratio

-

feed ratio

lactide:lactide 70:30

feed ratio

p-dioxanone:glycolide 90:10±5

color

clear colorless to pale yellow

color

clear colorless to pale yellow

color

off-white to light yellow

color

white to off-white

General description

In addition to use in biomolecule-polymer conjugates, PEOGMA has also seen wide spread use in tissue engineering applications, such as hydrogel synthesis. Aldehyde-functionalized PM(EO)2MA-co-OEGMA can be readily used with the corresponding hydrazide-functionalized POEGMA or PM(EO)2MA-co-OEGMA for rapid gelation via reversible hydrazone bond formation. Due to the reversibility of the bond formation and the low viscosity of the precursors, resulting hydrogels can be used as injectable tissue engineering matrices, local drug delivery vehicles for small molecules, or as joint lubricants. In addition, the physical properties of the resulting hydrogels, such as LCST, gelation rates, swelling kinetics, degredation kinetics, and mechanical properties, can all be readily controlled by solution concentration and the ratios of each solution.
Poly(diethylene glycol methacrylate)-co-(oligoethylene glycol methacrylate), (PM(EO)2MA-co-OEGMA) is a comb-shaped, graft copolymer consisting of hydrophilic oligomer polyethylene glycol (PEG) chains grafted to a hydrophobic polymethacrylate backbone. In this material, the PEG chains are either diethylene glycol units or oligomer PEG (n=8-9) units. Resulting material properties can be tuned by controlling the ratio of each component. POEGMA has been suggested as a viable alternative to PEG in biological and biomaterial applications. POEGMA has been reported to improve pharmacokinetic properties of protein and peptide conjugates, enhance the stability and gene silencing efficiency of siRNAs, as an anti-fouling surface for biosensors, and eliminate PEG antigenicity.

Preparation Note

This product is provided as a 25 wt%solution in water, ready to be diluted for your specific application. Please see the technical bulletin on the product page for dilution instructions and hydrogel preparation instructions.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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