Hydroxy-PEG4-t-butyl ester

Name: Hydroxy-PEG4-t-butyl ester
Brand: ALDRICH
Price: 300 USD
Availability: InStock

Synonym(s):

tert-Butyl-1-hydroxy-3,6,9,12-tetraoxapentadecan-15-oate, HO-PEG4-CO-OtBu

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₃₀O₇

CAS Number:

518044-32-1

Molecular Weight:

322.39

MDL number:

MFCD11041117

UNSPSC Code:

51171641

NACRES:

NA.22

Assay:

≥95%

Form:

liquid

Key Documents

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SMILES string

O=C(OC(C)(C)C)CCOCCOCCOCCOCCO

InChI

1S/C15H30O7/c1-15(2,3)22-14(17)4-6-18-8-10-20-12-13-21-11-9-19-7-5-16/h16H,4-13H2,1-3H3

InChI key

FJRDXEGYAVAMLB-UHFFFAOYSA-N

assay

≥95%

form

liquid

reaction suitability

reagent type: cross-linking reagent

refractive index

n/D 1.4492

density

1.04746 g/mL

functional group

ester, hydroxyl

storage temp.

2-8°C

Related Categories

Chemical Biology

Crosslinkers

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Show Differences

1 of 4

This Item	902578	902535	902659
Sigma-Aldrich 902586 Hydroxy-PEG4-t-butyl ester	Sigma-Aldrich 902578 Hydroxy-PEG6-t-butyl ester	Sigma-Aldrich 902535 Amino-PEG4-t-butyl ester	Sigma-Aldrich 902659 Amino-PEG6-t-butyl ester
assay ≥95%	assay ≥95%	assay -	assay -
reaction suitability reagent type: cross-linking reagent	reaction suitability reagent type: cross-linking reagent	reaction suitability reagent type: cross-linking reagent	reaction suitability reagent type: cross-linking reagent
storage temp. 2-8°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
form liquid	form liquid	form liquid	form liquid
density 1.04746 g/mL	density 1.068	density 1.04479 g/mL	density 1.06581 g/mL
refractive index n/D 1.4492	refractive index n/D 1.454	refractive index n/D 1.4508	refractive index n/D 1.4562

Application

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Other Notes

Recruiting cytotoxic T cells to folate-receptor-positive cancer cells

Syntheses and characterizations of novel pyrrolocoumarin probes for SNAP-tag labeling technology

High density orthogonal surface immobilization via photoactivated copper-free click chemistry

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Proline-functionalized magnetic core-shell nanoparticles as efficient and recyclable organocatalysts for aldol reactions.

Yacob Z, et al

Advanced Synthesis & Catalysis, 354(17), 3259-3264 (2012)

A new route for the synthesis of 1-amino-3,6,9,12-?tetraoxapentadecan-15-oic acid.

Wu X, et al.

J. Chem. Res. (M), 40(6), 368-370 (2016)

High density orthogonal surface immobilization via photoactivated copper-free click chemistry.

Sara V Orski et al.

Journal of the American Chemical Society, 132(32), 11024-11026 (2010-08-12)

Surfaces containing reactive ester polymer brushes were functionalized with cyclopropenone-masked dibenzocyclooctynes for the light activated immobilization of azides using catalyst-free click chemistry. The photodecarbonylation reaction in the amorphous brush layer is first order for the first 45 s with a

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Sumith A Kularatne et al.

Angewandte Chemie (International ed. in English), 52(46), 12101-12104 (2014-02-28)

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Journal of nucleic acids, 2011, 805253-805253 (2011-10-21)

Nowadays, RNA synthesis has become an essential tool not only in the field of molecular biology and medicine, but also in areas like molecular diagnostics and material sciences. Beyond synthetic RNAs for antisense, aptamer, ribozyme, and siRNA technologies, oligoribonucleotides carrying

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