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902586

Sigma-Aldrich

Hydroxy-PEG4-t-butyl ester

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Synonym(s):
tert-Butyl-1-hydroxy-3,6,9,12-tetraoxapentadecan-15-oate, HO-PEG4-CO-OtBu
Empirical Formula (Hill Notation):
C15H30O7
CAS Number:
Molecular Weight:
322.39

assay

≥95%

form

liquid

reaction suitability

reagent type: cross-linking reagent

refractive index

n/D 1.4492

density

1.04746 g/mL

functional group

ester
hydroxyl

storage temp.

2-8°C

SMILES string

O=C(OC(C)(C)C)CCOCCOCCOCCOCCO

InChI

1S/C15H30O7/c1-15(2,3)22-14(17)4-6-18-8-10-20-12-13-21-11-9-19-7-5-16/h16H,4-13H2,1-3H3

InChI key

FJRDXEGYAVAMLB-UHFFFAOYSA-N

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Hydroxy-PEG4-t-butyl ester

902586

Hydroxy-PEG4-t-butyl ester

Hydroxy-PEG6-t-butyl ester ≥95%

902578

Hydroxy-PEG6-t-butyl ester

Amino-PEG4-t-butyl ester

902535

Amino-PEG4-t-butyl ester

Amino-PEG6-t-butyl ester

902659

Amino-PEG6-t-butyl ester

reaction suitability

reagent type: cross-linking reagent

reaction suitability

reagent type: cross-linking reagent

reaction suitability

reagent type: cross-linking reagent

reaction suitability

reagent type: cross-linking reagent

refractive index

n/D 1.4492

refractive index

n/D 1.454

refractive index

n/D 1.4508

refractive index

n/D 1.4562

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

form

liquid

form

liquid

form

liquid

form

liquid

density

1.04746 g/mL

density

1.068

density

1.04479 g/mL

density

1.06581 g/mL

Application

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

related product

Product No.
Description
Pricing

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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