Amino-PEG6-t-butyl ester

Name: Amino-PEG6-t-butyl ester
Brand: ALDRICH

Synonym(s):

tert-Butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate, H₂N-PEG6-CH₂CH₂COOtBu

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₃₉NO₈

CAS Number:

1286281-32-0

Molecular Weight:

409.51

MDL number:

MFCD13184944

UNSPSC Code:

51171641

NACRES:

NA.22

Key Documents

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form

liquid

reaction suitability

reagent type: cross-linking reagent

refractive index

n/D 1.4562

density

1.06581 g/mL

functional group

amine
ester

storage temp.

−20°C

SMILES string

NCCOCCOCCOCCOCCOCCOCCC(OC(C)(C)C)=O

InChI

1S/C19H39NO8/c1-19(2,3)28-18(21)4-6-22-8-10-24-12-14-26-16-17-27-15-13-25-11-9-23-7-5-20/h4-17,20H2,1-3H3

InChI key

QGSFECNPSLZGGT-UHFFFAOYSA-N

Related Categories

Chemical Biology

Crosslinkers

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Show Differences

1 of 4

This Item	902535	902578	902586
Sigma-Aldrich 902659 Amino-PEG6-t-butyl ester	Sigma-Aldrich 902535 Amino-PEG4-t-butyl ester	Sigma-Aldrich 902578 Hydroxy-PEG6-t-butyl ester	Sigma-Aldrich 902586 Hydroxy-PEG4-t-butyl ester
reaction suitability reagent type: cross-linking reagent	reaction suitability reagent type: cross-linking reagent	reaction suitability reagent type: cross-linking reagent	reaction suitability reagent type: cross-linking reagent
form liquid	form liquid	form liquid	form liquid
refractive index n/D 1.4562	refractive index n/D 1.4508	refractive index n/D 1.454	refractive index n/D 1.4492
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C
density 1.06581 g/mL	density 1.04479 g/mL	density 1.068	density 1.04746 g/mL
functional group amine	functional group amine, ester	functional group ester, hydroxyl	functional group ester, hydroxyl

Application

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

MKCS9896

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