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905046

Sigma-Aldrich

Iron oxide incorporated conjugated polymer nanoparticles

fluorescence λem 550 nm, 100 μg/mL in H2O

Synonym(s):
Fluorescent magnetic nanoparticles, Conjugated polymer nanoparticles, Magneto-conjugated polymer nanoparticles, Fluorescent nanoparticles

form

nanoparticles

concentration

100 μg/mL in H2O

fluorescence

λem 550 nm

storage temp.

2-8°C

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Application

Iron oxide containing conjugated polymer nanoparticles are water-soluble nanoparticles compromising of light-emitting polymer and iron oxide. The presence of iron oxide in core makes these fluorescent nanoparticles distinctly different than conventional dyes as it allows their manipulation with a magnetic field. These nanoparticles possess a ′core-shell′ structure where light-emitting polymer and iron oxide are encapsulated in biocompatible surfactant.
The ′core-shell′ structure consisting of polymer and iron oxide in the core and the biocompatible surfactant in the surrounding shell allows easy covalently bonding of these nanoparticles with biomolecules such streptavidin, antibodies, proteins, nucleic acids, etc and make them suitable for the following applications:
  • Fluorescence Microscopy (high content screening, live cell tracking and 3-D cell imaging)
  • Immunohistochemistry and Immunocytochemistry
  • Flow Cytometry
  • Rapid Diagnostic Tests (RDTs)
  • Tissue Imaging
  • 2-Photon Imaging
  • NIR Imaging

Storage and Stability

The robustness of CPNs enables them to be used under high intensity illumination and in extreme experimental conditions if required, while their 24-month shelf-life permits convenient storage at ambient temperatures.

Storage Class Code

12 - Non Combustible Liquids

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Magnetic conjugated polymer nanoparticles as bimodal imaging agents.
Howes P, Green M, Bowers A, et al.
Journal of the American Chemical Society, 132(28), 9833-9842 (2010)
General synthesis of high-performing magneto-conjugated polymer core?shell nanoparticles for multifunctional theranostics
H Yan et al.
Nano Research, 10, 704-704 (2017)
General synthesis of high-performing magneto-conjugated polymer core-shell nanoparticles for multifunctional theranostics
Yan H, et al.
Nano Research, 10(2), 704-717 (2017)
Loading Graphene Quantum Dots into Optical-Magneto Nanoparticles for Real-Time Tracking In Vivo
Wang Y, et al.
Materials, 12(13), 2191-2191 (2019)
Fluorescent magnetic nanoparticles for biomedical applications
Chekina N, et al.
Journal of Materials Chemistry, 21(21), 7630-7639 (2011)

Articles

Use of Iron Oxide Incorporated Conjugated Polymer Nanoparticles for Bioimaging

Our highly fluorescent iron oxide incorporated conjugated polymer nanoparticles (CPNs) have an iron oxide and semiconductor light emitting polymer core, encapsulated within a biocompatible surfactant. The multi-modal particles can be used in both fluorescence and magnetic resonance imaging. Learn more about their exceptional brightness and application versatility in our technical spotlight.

Applications of Iron Oxide Incorporated Conjugated Polymer Nanoparticles

As a result of their properties, CPNs can deliver enhanced sensitivity, improved stability, and rapid, reliable results across various life science assays, including lateral flow and western blot. This innovative technology may provide benefits in the lab and allow the development of portable, point-of-care rapid diagnostic tests to help meet current and future healthcare needs.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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