905267

(6-Bromohexyl)triphenylphosphonium bromide

≥95%

• Synonym(s): Bromohexane TPP mitochondrial tag, Mitochondria-targeting probe building block, Phosphonium lipocation tag
• Empirical Formula (Hill Notation): C₂₄H₂₇Br₂P
• CAS Number: 83152-22-1
• Molecular Weight: 506.25
• MDL number: MFCD32197454
• UNSPSC Code: 12352101
• NACRES: NA.22

Properties

• assay: ≥95%
• form: solid
• reaction suitability: reagent type: ligand
• functional group: phosphine
• storage temp.: 2-8°C
• SMILES string: BrCCCCCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3.[Br]
• InChI: 1S/C24H27BrP.BrH/c25-20-12-1-2-13-21-26(22-14-6-3-7-15-22,23-16-8-4-9-17-23)24-18-10-5-11-19-24;/h3-11,14-19H,1-2,12-13,20-21H2;1H/q+1;/p-1
• InChI key: RJXLPJGHUJHULP-UHFFFAOYSA-M

Description

Application

Mitochondria perform several functions in the cell, and dysfunction has been implicated in various organ systems and disease states, including neurodegenerative disorders and cancers. The targeting of small molecules to the mitochondria can help to probe and better understand this relationship. This bromohexane triphenylphosphine (TPP) tag is conjugated to small molecules to localize them to the mitochondria in cells where the TPP cations facilitate both cellular uptake and accumulation in the mitochondria.

Other Notes

Targeting lipophilic cations to mitochondria

Photoswitchable polyfluorophores based on perylenemonoimide-dithienylethene conjugates as super-resolution MitoTrackers

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable