Skip to Content
MilliporeSigma
Get up to 22% off for Pi Day through March 27.Save Now

909076

Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide)

average Mn (1,700-1,500-1,700), lactide:glycolide (95:5)

Synonym(s):

PLGA-PEG-PLGA

Slide 1 of 2
Sign In to View Organizational & Contract Pricing.

Select a Size

1 G

$465.00

$465.00

Available to ship TODAYDetails

​
Request a Bulk Order

About This Item

Linear Formula:
H((C3H4O2)x(C2H2O2)y)m((C2H4O)z)nO((C3H4O2)x(C2H2O2)y)mH
NACRES:
NA.23
UNSPSC Code:
51171641

Key Documents

View All Documentation

Skip To

Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

form

semisolid

feed ratio

lactide:glycolide (95:5)

mol wt

PEG average Mn 1,500 (by NMR), PLGA average Mn 3,400 (by NMR), average Mn (1,700-1,500-1,700)

color

white to tan

PDI

≤2.0, <1.1 (Typical PEG PDI )

storage temp.

−20°C

Looking for similar products? Visit Product Comparison Guide

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
908843900664911399
Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide) average Mn (1,700-1,500-1,700), lactide:glycolide (95:5)

Sigma-Aldrich

909076

Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide)

Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide) average Mn (1,600-1,500-1,600), lactide:glycolide 75:25

Sigma-Aldrich

908843

Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide)

Poly(D,L-lactide-co-glycolide)(50:50)-b-poly(ethylene glycol) 10k-2k

Sigma-Aldrich

900664

Poly(D,L-lactide-co-glycolide)(50:50)-b-poly(ethylene glycol)

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) PEG average Mn 2,000, PLGA average Mn 10,000, lactide:glycolide 80:20

Sigma-Aldrich

911399

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

form

semisolid

form

semisolid

form

chunks

form

powder or chunks

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

feed ratio

lactide:glycolide (95:5)

feed ratio

lactide:glycolide 75:25

feed ratio

-

feed ratio

lactide:glycolide 80:20

mol wt

PEG average Mn 1,500 (by NMR)

mol wt

PEG average Mn 1,500 (by NMR), PLGA average Mn 3,200 (by NMR), average Mn (1,600-1,500-1,600)

mol wt

-

mol wt

PEG average Mn 2,000 (by NMR), PLGA average Mn 10,000 (by NMR)

color

white to tan

color

white to tan

color

-

color

off-white to faint brown

PDI

≤2.0

PDI

≤2.0, <1.1 (Typical PEG PDI )

PDI

-

PDI

-

Application

PLGA-PEG-PLGA is an amphiphilic triblock copolymer which can self-assemble into micelles in aqueous medium due to the hydrophobic interactions present in the hydrophobic segments. The PEG segment imparts hydrophilicity and improves the biocompatibility of the copolymer. The PLGA segment forms a hydrophobic core and can solubilize hydrophobic drugs. These copolymers are widely used as nanocarriers for the sustained release of drugs. Also this polymer exhibits thermogelation behavior. When applied in biomedical applications, the temperature responsive nature of the copolymer can be tuned to induce an in situ gelation at physiological temperature to provide controlled drug release. These materials have been explored for biomedical applications as temperature-responsive biodegradable systems for drug delivery, tissue engineering and wound healing.

Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
MKCW4523
MKCT3771
MKCK8570

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Thermoreversible Gelation of PEG-PLGA-PEG Triblock Copolymer Aqueous Solutions.
Jeong B, et al.
Macromolecules, 32(21), 7064-7069 (1999)
Byeongmoon Jeong et al.
Biomacromolecules, 3(4), 865-868 (2002-07-09)
This paper reports on the thermogelling, biodegradable polymer formulations based on poly(DL-lactic acid-co-glycolic acid)/(poly(ethylene glycol) graft copolymers for in vivo biomedical applications using animal models. The description includes diabetic control by sustained insulin delivery and cartilage repair by chondrocyte cell
Mingxi Qiao et al.
Die Pharmazie, 61(3), 199-202 (2006-04-08)
Biodegradable thermosensitive poly (DL-lactide-co-glycolide-b-ethylene glycol-b-DL-lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymers with DL-lactide/glycolide molar ratio ranging from 6/1 to 15/1 were synthesized from monomers of DL-lactide, glycolide and polyethylene glycol and were evaluated for sustained release of bee venom peptide in vitro. The
Jun Ge et al.
ACS nano, 6(1), 227-233 (2011-11-25)
We describe a new temperature and electric field dual-stimulus responsive nanoparticle system for programmed drug delivery. Nanoparticles of a conducting polymer (polypyrrole) are loaded with therapeutic pharmaceuticals and are subcutaneously localized in vivo with the assistance of a temperature-sensitive hydrogel
Chayanin Pratoomsoot et al.
Biomaterials, 29(3), 272-281 (2007-11-03)
Ocular trauma and disorders that lead to corneal blindness account for over 2 million new cases of monocular blindness every year. A popular ocular surface reconstruction therapy, amniotic membrane transplantation, has been shown to aid corneal wound repair. However, the

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service