909866

Sigma-Aldrich

Poly(2-(dimethylamino)ethyl methacrylate)

average Mn 10,000

Synonym(s):
Hydrophilic polymer, pH sensitive, PDMAEMA, pH-responsive
Linear Formula:
(C8H15NO2)n

form

powder or solid

mol wt

average Mn 10,000 (by GPC)
average Mn 10,000

color

white to faint yellow

PDI

≤1.4 (by GPC)

storage temp.

2-8°C

Application

Poly(2-(dimethylamino)ethyl methacrylate) is a pH-responsive polymer. pH-responsive polymers are a group of stimuli-responsive polymers that can respond to solution pH by undergoing structural and property changes such as surface activity, chain conformation, solubility, and configuration. The term “pH-responsive polymers” is commonly used to describe polymers having ionisable acidic or basic residues whose ionization depends on solution pH. The physical properties of the polymer, such as its chain conformation, configuration, and solubility, can be tailored by manipulating the pH or ionic strength. These unique properties of pH responsive polymer systems consequently make them very useful in various applications such as drug delivery, gene delivery, sensors, surfaces, membranes, and chromatography.
pH-sensitive polymer systems combined with nanotechnology could be utilized as an alternative strategy to traditional targeting systems to overcome major problems in current chemotherapy represented by non-specific tissue distribution of the drugs, tumor heterogeneity, and multidrug resistance (MDR) against anticancer drugs.

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

pH-Responsive polymers
Kocak G , et al.
Polym. Chem., 8, 144?176-144?176 (2017)
pH-sensitive polymers for drug delivery
Huh K M,et al.
Macromolecular Research, 20(3), 224?233-224?233 (2012)
Hong-ming Ding et al.
Scientific reports, 3, 2804-2804 (2013-10-01)
The major challenge in cancer therapy is to efficiently translocate drug molecules into cancer tumors without doing any damage to healthy tissues. Since there exist pH gradients between tumor and normal tissues, pH-sensitive materials may have great potential to overcome...
Cationic Salecan-based hydrogels for release of 5-fluorouracil.
Qi X, et al.
Royal Society of Chemistry Advances, 7, 14337-14347 (2017)
Prithankar Pramanik et al.
Macromolecular rapid communications, 37(18), 1499-1506 (2016-07-23)
The synthesis, micellar aggregation, and pH-triggered intracellular drug delivery ability of an amphiphilic statistical copolymer (P2) are studied. Two methacrylate derivatives, one containing a hydrophilic pendant and the other containing a hydrophobic pendant chain, are copolymerized to produce P2. The...

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