PDLA average Mn 16,000 (by NMR), PEG average Mn 5,000 (by NMR)
mol wt
PCL average Mn 5,000, PEG average Mn 5,000
mol wt
PEG Mn 4000-6000 g/mol (by NMR), PEG average Mn 5000, PLGA Mn 13500-16500 g/mol (by NMR), PLGA average Mn 15000
mol wt
-
storage temp.
−20°C
storage temp.
−20°C
storage temp.
−20°C
storage temp.
2-8°C
color
white to tan
color
white to off-white
color
white
color
-
Application
N-Hydroxysuccinimide ester-poly(ethylene glycol)-b-poly(D,L lactide) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PLA block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). The NHS functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.
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