Cerium doped iron oxide

branched polyethyleneimine and alginic acid shell

Core-shell type cerium doped iron oxide nanoparticles, Core-shell Ce3/4+ doped iron oxide nanoparticles, Core-shell type cerium doped maghemite nanoparticles


1.3 mg/mL in H2O

particle size

7-15 nm

storage temp.


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Functional shell formation with ceric ammonium nitrate (CAN, Ce-(NH4)2(NO3)6) on nanometer sized maghemite (γ-Fe2O3) particles has been shown to promote the binding of oxidized polyethyleneimine (PEI) to their surface, which mitigates their acute in vivo toxicity and enables the applications of cerium doped maghemite nanoparticles in high efficacy gene silencing. The addition of the alginic acid to the shell enables excellent biocompatibility and surface functionality (carboxylic acid) for facile functionalization of choice targeting ligands. In addition these nanoparticles find applications in magnetic resonance imaging (MRI) and drug delivery.

Legal Information

The Product is being introduced through Materials Transfer Agreement with ′Bar Ilan University, Israel′.

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Shih-Hsiang Liao et al.
International journal of nanomedicine, 10, 3315-3327 (2015-05-26)
Hyperthermia is one of the promising treatments for cancer therapy. However, the development of a magnetic fluid agent that can selectively target a tumor and efficiently elevate temperature while exhibiting excellent biocompatibility still remains challenging. Here a new core-shell nanostructure...
Magali Gary-Bobo et al.
Photodiagnosis and photodynamic therapy, 9(3), 256-260 (2012-09-11)
Mesoporous silica nanoparticles (MSN) for photodynamic therapy (PDT) were coated with poly-(L-lysine) and hyaluronic acid (HA) by using the layer-by-layer method. HA is able to target cancer cells over-expressing the corresponding CD44 receptor. MSN functionalized with HA (MSN-HA) were more...
Ce3/4+ cation-functionalized maghemite nanoparticles towards siRNA-mediated gene silencing
Israel L L et al.
Journal of Material Chemistry B: Materials for Biology and Medicine, 2, 6215-6225 (2014)
Liron Limor Israel et al.
ACS applied materials & interfaces, 7(28), 15240-15255 (2015-06-30)
A ceric ammonium nitrate (CAN)-based doping step was used for the fabrication of core maghemite nanoparticles (NPs) that enabled the obtainment of colloid particles with a view to a high-level nanoparticle (NP) surface doping by Ce(III/IV). Such doping of Ce(III/IV)...
E Lellouche et al.
Bioconjugate chemistry, 26(8), 1692-1701 (2015-06-10)
Silencing of RNA to knock down genes is currently one of the top priorities in gene therapies for cancer. However, to become practical the obstacle of RNA delivery needs to be solved. In this study, we used innovative maghemite (γ-Fe2O3)...

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