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910791

Poly(ethylene glycol)-block-polyethyleneimine

PEG Mn 750, PEI Mn 15k

Synonym(s):

Linear poly(ethylene glycol)-block-polyethylenimine, Nanopatterning, PEG-b-PEI, PEG-PEI, block-copolymers

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500 MG

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About This Item

Linear Formula:
CH3(C2H4O)m(C2H5N)nOH
NACRES:
NA.23
UNSPSC Code:
12162002

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form

powder or solid

mol wt

PEG Mn 750, PEG Mw 750 Da, PEI Mn 15k, PEI Mw 10,000 Da

color

white to pale yellow

storage temp.

2-8°C

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This Item
927309927317927295
Poly(ethylene glycol)-block-polyethyleneimine PEG Mn 750, PEI Mn 15k

Sigma-Aldrich

910791

Poly(ethylene glycol)-block-polyethyleneimine

Linear polyethylenimine-block-poly(ethylene glycol) PEG average Mn 2,000, PEI average Mn 20,000

Sigma-Aldrich

927309

Linear polyethylenimine-block-poly(ethylene glycol)

Linear polyethylenimine-block-poly(ethylene glycol) PEG average Mn 750, PEI average Mn 15,000

Sigma-Aldrich

927317

Linear polyethylenimine-block-poly(ethylene glycol)

Linear polyethylenimine-block-poly(ethylene glycol) PEG average Mn 2,000, PEI average Mn 10,000

Sigma-Aldrich

927295

Linear polyethylenimine-block-poly(ethylene glycol)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

mol wt

PEG Mn 750, PEI Mn 15k, PEG Mw 750 Da, PEI Mw 10,000 Da

mol wt

PEG Mn 2,000 Da, PEG average Mn 2,000, PEI Mn 20,000 Da, PEI average Mn 20,000

mol wt

PEG Mn 750 Da, PEG average Mn 750, PEI Mn 15,000 Da, PEI average Mn 15,000

mol wt

PEG Mn 2,000 Da, PEG average Mn 2,000, PEI Mn 10,000 Da, PEI average Mn 10,000

form

powder or solid

form

powder or solid

form

solid

form

powder or solid

color

white to pale yellow

color

white to pale yellow

color

white to yellow

color

white to pale yellow

Application

Gene therapy using polymeric nonviral vectors promises considerable advances in the treatment of many genetic and acquired diseases due to the carrier safety and low immunogenicity profiles. Poly(ethyleneimine) is one of the most commonly used cationic polymers for gene delivery applications. Copolymers of PEI and hydrophilic poly(ethylene glycol) have been designed to provide a stealth-like shield around polymer/DNA complexes, reducing nonspecific interactions, inhibiting activation of the reticuloendothelial system, and prolonging the half-life of the complexes in the blood.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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B Brissault et al.
Biomacromolecules, 7(10), 2863-2870 (2006-10-10)
The study of ethyloxazoline/methyloxazoline (EtOXZ/MeOXZ) copolymerization, initiated by methyl tosylate (MeOTs), showed that (i) incorporation of MeOXZ units into random copolymer becomes effective over DP = 100 and (ii) propagation process proceeds with negligible transfer to monomer up to a
Pallab Banerjee et al.
Bioconjugate chemistry, 17(1), 125-131 (2006-01-19)
A block copolymer of a hyperbranched poly(ethylene glycol)-like core and linear polyethylenimine (HBP) was synthesized by a facile synthetic route that included (1) a single-step cationic copolymerization of diepoxy and polyhydroxyl monomers, (2) derivatization of hydroxyl groups of the core
Dagmar Fischer et al.
Drug metabolism and disposition: the biological fate of chemicals, 32(9), 983-992 (2004-08-21)
The in vivo body distribution and the pharmacokinetics of a 20mer double-stranded nuclear factor kappaB decoy oligodeoxynucleotide (ODN) complexed with 25-kDa poly(ethylene imine) (PEI), low molecular weight 2.7-kDa PEI, and PEGylated PEI [bPEI(25k)-glPEG(550)(50)] after intravenous injection were studied in BALB/c

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