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911143

Sigma-Aldrich

HO-PEG24-propanoic acid t-butyl ester

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Synonym(s):
HO-PEG-tert-butyl ester, Hydroxyl PEG tert-butyl ester, Hydroxyl-PEG-tert-butyl ester
Empirical Formula (Hill Notation):
C55H110O27
CAS Number:
Molecular Weight:
1203.45
MDL number:

form

solid or liquid

mol wt

average Mn 1,200 (by NMR)

reaction suitability

reagent type: chemical modification reagent
reactivity: amine reactive

color

white to off-white

Ω-end

(tert-Butyl ester)

α-end

hydroxyl

polymer architecture

shape: linear
functionality: monofunctional

storage temp.

−20°C

Application

Polyethylene glycols (PEGs) are FDA approved hydrophilic polymers. They are non-toxic, non-immunogenic and non-antigenic, and are widely used in a varity of biomedical applications such as bioconjugation, drug delivery, surface functionalization, and tissue engineering. The propionic acid group in HO-PEG-propanoic acid t-butyl ester is protected, preventing self-coupling.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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The CRISPR/Cas9 system has recently emerged as a highly specific, efficient, and versatile gene editing technology that can be utilized to build disease models and correct diseased genes. Safe and effective delivery vectors for the CRISPR/Cas9 system are in critical need to enable clinical development and future applications of CRISPR/Cas9 systems. Professor Yang Liu summarizes recent progress in nonviral nanoparticle approaches for CRISPR/Cas9 delivery.

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