911445

Sigma-Aldrich

Polyester bis-MPA dendron, 4 Rhodamine, 1 carboxyl (core)

generation 2

Synonym(s):
Bis-MPA dendron, Fluoresenct linker, Fluoresent dendron
Empirical Formula (Hill Notation):
C127H142Cl4N8O18
Molecular Weight:
2210.34

form

solid

mol wt

generation 2

no. Surface Groups

4

color

red to pink

functional group

carboxyl (core)

storage temp.

−20°C

Inchi Code

1S/C127H141N8O18.4ClH/c1-20-128(21-2)82-52-60-98-106(68-82)150-107-69-83(129(22-3)23-4)53-61-99(107)114(98)90-44-36-40-48-94(90)118(136)144-78-126(18,79-145-119(137)95-49-41-37-45-91(95)115-100-62-54-84(130(24-5)25-6)70-108(100)151-109-71-85(55-63-101(109)115)131(26-7)27-8)123(142)148-76-125(17,122(140)141)77-149-124(143)127(19,80-146-120(138)96-50-42-38-46-92(96)116-102-64-56-86(132(28-9)29-10)72-110(102)152-111-73-87(57-65-103(111)116)133(30-11)31-12)81-147-121(139)97-51-43-39-47-93(97)117-104-66-58-88(134(32-13)33-14)74-112(104)153-113-75-89(59-67-105(113)117)135(34-15)35-16;;;;/h36-75H,20-35,76-81H2,1-19H3;4*1H/q+3;;;;/p-3

InChI key

FSUBYGYPRUCEAS-UHFFFAOYSA-K

Related Categories

General description

  • Polymer architecture: Dendron
  • End Group Functionality: Rhodamine
  • Bis-MPA : 2,2-Bis(hydroxymethyl)propionic acid

Application

Bis-MPA dendritic molecules are based on 2,2-bismethylolpropionicacid (bis-MPA) building blocks. The hydrolysable linkers presented in this type of polymers allow their degradation into byproducts that can be reabsorbed by the body or into excretable non-toxic small molecules. Therefore, this group of dendritic polymers is biocompatible and biodegradable, making them suitable for biomedical applications.
The core of this product is functionalized by carboxyl groups, which can be readily used in bioconjugation. The rhodamine labeled corona allows for application in bioimaging.

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Patrik Stenström et al.
Molecules (Basel, Switzerland), 23(8) (2018-08-17)
Herein, we present the first evaluation of cationic dendrimers based on 2,2-bis(methylol)propionic acid (bis-MPA) as nonviral vectors for transfection of short interfering RNA (siRNA) in cell cultures. The study encompassed dendrimers of generation one to four (G1⁻G4), modified to bear...
Chemistry of multifunctional polymers based on bis-MPA and their cutting-edge applications.
Garcia-Gallego S, et al
Progress in Polymer Science, 48, 85-110 (2015)
Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been...
Articles
Professor Michael Malkoch provides an overview of the unique properties of dendritic molecules and their application in biomedical fields. He highlights bis-MPA dendritic scaffolds as a promising biodegradable and biocompatible platform for drug delivery applications
Read More

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