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911496

Polyester bis-MPA dendron, 4 carboxyl, 1 Rhodamine (core)

generation 2

Synonym(s):

Bis-MPA dendron, Fluorescent linker, Fluoresent dendron

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50 MG

$388.00

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About This Item

Empirical Formula (Hill Notation):
C67H87ClN2O28
Molecular Weight:
1403.86
UNSPSC Code:
12162002
NACRES:
NA.23

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form

solid

mol wt

generation 2

no. Surface Groups

4

color

red to pink

functional group

(Rhodamine(core))

storage temp.

−20°C

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Polyester bis-MPA dendron, 4 carboxyl, 1 Rhodamine (core) generation 2

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911496

Polyester bis-MPA dendron, 4 carboxyl, 1 Rhodamine (core)

Polyester bis-MPA dendron, 4 NHBoc 1 NHS (core), generation 2

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Polyester bis-MPA dendron, 4 NHBoc

Polyester bis-MPA dendron 2 NHBoc, 1 azide (core) generation 1

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901311

Polyester bis-MPA dendron 2 NHBoc, 1 azide (core)

Polyester bis-MPA dendron 2 NHBoc, 1 Biotin (core) generation 1

Sigma-Aldrich

911577

Polyester bis-MPA dendron 2 NHBoc, 1 Biotin (core)

form

solid

form

solid (Viscous)

form

solid

form

solid (Viscous)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

mol wt

generation 2

mol wt

generation 2

mol wt

generation 1

mol wt

generation 1

no. Surface Groups

4

no. Surface Groups

4

no. Surface Groups

2

no. Surface Groups

2

color

red to pink

color

colorless to white

color

white to off-white

color

colorless to white

functional group

(Rhodamine(core))

functional group

-

functional group

azide (core)

functional group

biotin (core)

General description

  • Polymer architecture: Dendron
  • End Group Functionality: Carboxyl
  • Bis-MPA: 2,2-Bis(hydroxymethyl)propionic acid

Application

Bis-MPA dendritic molecules are based on 2,2-bismethylolpropionicacid (bis-MPA) building blocks. The hydrolysable linkers presented in this type of polymers allow their degradation into byproducts that can be reabsorbed by the body or into excretable non-toxic small molecules. Therefore, this group of dendritic polymers is biocompatible and biodegradable, making them suitable for biomedical applications.
The corona of this product is functionalized by carboxyl groups, which can be readily used in bioconjugation. The rhodamine labeled core allows its application in bioimaging.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCM4818

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Patrik Stenström et al.
Molecules (Basel, Switzerland), 23(8) (2018-08-17)
Herein, we present the first evaluation of cationic dendrimers based on 2,2-bis(methylol)propionic acid (bis-MPA) as nonviral vectors for transfection of short interfering RNA (siRNA) in cell cultures. The study encompassed dendrimers of generation one to four (G1⁻G4), modified to bear
Chemistry of multifunctional polymers based on bis-MPA and their cutting-edge applications.
Garcia-Gallego S, et al
Progress in Polymer Science, 48, 85-110 (2015)
Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been

Articles

Dendritic Polyester Scaffolds for Drug Delivery

Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

New Multi-Dendrimer Platforms for Supramolecular Assembly

Dendrimers, polymer nanostructures, are synthesized for specific purposes by manipulating critical nanoscale design parameters (CNDPs).

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