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Sigma-Aldrich

NanoFabTx microfluidic - micro

device kit for synthesis of 10-30 μm particles

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Synonym(s):
Microfluidic kit, Microparticle, NanoFabTx device kit, Nanoformulation

description

Microfludic device kit for synthesizing 10-30 μm microparticles

Kit components :

  • Microfluidic chip x 1
  • Tubings and accessories

Quality Level

application(s)

advanced drug delivery

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This Item
911860911925911593
description

Microfludic device kit for synthesizing 10-30 μm microparticles

Kit components :

  • Microfluidic chip x 1
  • Tubings and accessories

description

Microfludic device kit for synthesizing 1-5 μm microparticles

Kit components :

  • Microfluidic chip x 1
  • Tubings and accessories

description

Microfludic hardware kit component for synthesizing 1-5 μm microparticles

Kit components :

  • Microfluidic chip x 1

description

Microfludic device kit for synthesizing nanparticles

Kit components :

  • Microfluidic chip x 1
  • Tubings and accessories

application(s)

advanced drug delivery

application(s)

advanced drug delivery

application(s)

advanced drug delivery

application(s)

advanced drug delivery

General description

NanoFabTx Microfluidic - micro device kit is designed to work with the NanoFabTx - micro reagent kits like (Cat. No. 912212) for the synthesis of 10-30 μm particles. The device kit includes a comprehensive protocol, pre-assembled microfluidic chip manifold, tubing, and required accessories and is compatible with either the Dolomite microfluidics system or a standard syringe pump (compatible microfluidics system or syringe pump required separately).

Application

NanoFabTx Microfluidic - micro device kit in combination with the NanoFabTx - micro reagent kits (Cat. No. 912212) can be used to create drug-encapsulating polymeric microparticles 10-30 μm in size. Because of the adjustable flow rate, small reaction window, and adjustable concentrations, microfluidic-based synthesis is a powerful tool for fabricating size-controlled particles to encapsulate drugs, small molecules, mRNA, DNA, and proteins. The chip geometries and flow parameters enable facile, scalable synthesis of monodispersed particles with consistent size and drug loading to facilitate rapid formulation screening.

Features and Benefits

  • Simplifies polymer chemistry of microfluidic formulation development for enhancing drug bioavailability
  • Accelerates optimization of drug encapsulation and loading efficiency in microparticles
  • Provides step-by-step microfluidic-based protocols developed and tested by our formulation scientists
  • Minimizes waste of expensive reagents

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

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25G
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705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

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Samar Damiati et al.
Genes, 9(2) (2018-02-22)
Microfluidic devices present unique advantages for the development of efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Compared to bulk methods, by efficiently controlling the geometries of the fabricated chip and the flow
Andrew Gdowski et al.
Journal of nanobiotechnology, 16(1), 12-12 (2018-02-13)
The process of optimization and fabrication of nanoparticle synthesis for preclinical studies can be challenging and time consuming. Traditional small scale laboratory synthesis techniques suffer from batch to batch variability. Additionally, the parameters used in the original formulation must be
Xuanyu Li et al.
Advanced drug delivery reviews, 128, 101-114 (2017-12-27)
Microfluidic chips allow the rapid production of a library of nanoparticles (NPs) with distinct properties by changing the precursors and the flow rates, significantly decreasing the time for screening optimal formulation as carriers for drug delivery compared to conventional methods.

Articles

NanoFabTx™ Drug Delivery Formulations and Microfluidic Device Kits

Our NanoFabTx™ platform helps accelerate your drug development by providing ready-to-use formulations and microfluidic devices for reproducible synthesis of nano- to micro-sized particles and liposomes.

NanoFabTx™ Nanoparticle and mRNA Liposome Formulation Using the NanoAssemblr®

NanoFabTX drug delivery formulation kits and lipids mixes for mRNA, nucleic acid, and small molecule delivery in lipid nanoparticles, liposomes and polymeric nanoparticles prepared using Precision NanoSystems microfluidic NanoAssemblr

Flash NanoPrecipitation (FNP) – Principles and Applications in Medical Imaging and Drug Delivery

Professor Robert K. Prud’homme introduces flash nanoprecipitation (FNP) for nanoparticle fabrication, which is a scalable, rapid mixing process for nanoparticle formulations.

Microfluidics for Nanoencapsulation of Nucleic Acids Using Polymeric Carriers

Microfluidic assembly can efficiently overcome the general disadvantages of polyamine nanoencapsulation of nucleic acids, such as a less defined morphology and composition, polydispersity, and poor reproducibility.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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