The AgNO3 titration is used to determine the HCl content in the molecule, and the mentioned 12.9% is indeed the HCl content.
915572
Pomalidomide-dipiperazine-NH2 hydrochloride
≥95%
Synonym(s):
4-(4-(4-(2-Aminoethyl)piperazine-1-carbonyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride, Crosslinker−E3 ligase ligand conjugate, Pomalidomide conjugate, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader
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| Size/SKU | Availability | Price |
|---|---|---|
50 mg | Estimated to ship onSeptember 01, 2026fromMILWAUKEE | $474.00 |
About This Item
Empirical Formula (Hill Notation):
C24H31N7O5 · xHCl
Molecular Weight:
497.55 (free base basis)
UNSPSC Code:
12352101
NACRES:
NA.22
ligand
pomalidomide
Quality Segment
assay
≥95%
form
powder
reaction suitability
reactivity: carboxyl reactive, reagent type: ligand-linker conjugate
functional group
amine
storage temp.
2-8°C
SMILES string
O=C(N(C1CCC(NC1=O)=O)C2=O)C3=C2C=CC=C3N4CCN(C(N5CCN(CCN)CC5)=O)CC4
InChI key
KLJJLERZEMIGTG-UHFFFAOYSA-N
Application
Protein degrader building block Pomalidomide-dipiperazine-NH2 hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a rigid linker, and a pendant amine for reactivity with an acid on the target warhead. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Other Notes
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Portal: Building PROTAC® Degraders for Targeted Protein Degradation
Targeted Protein Degradation by Small Molecules
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Portal: Building PROTAC® Degraders for Targeted Protein Degradation
Targeted Protein Degradation by Small Molecules
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
1 of 1
This Item | |||
|---|---|---|---|
| functional group amine | functional group amine | functional group azide | functional group amine |
| reaction suitability reactivity: carboxyl reactive, reagent type: ligand-linker conjugate | reaction suitability reactivity: carboxyl reactive, reagent type: ligand-linker conjugate | reaction suitability - | reaction suitability reactivity: carboxyl reactive, reagent type: ligand-linker conjugate |
| assay ≥95% | assay ≥95% | assay ≥95% | assay ≥95% |
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| form powder | form powder | form powder | form powder |
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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Can the mentioned number (12.9%) be considered as the percentage of HCl, given that the amount of HCl in general is typically determined by titration? Additionally, the only test listed is "Titration with AgNO3," but it does not specify what is being titrated.
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