916064

Sigma-Aldrich

cis-Hexamethylphosphetane oxide

≥95%

Synonym(s):
cis-1,2,2,3,4,4-Hexamethylphosphetane 1-oxide
Empirical Formula (Hill Notation):
C9H19OP
CAS Number:
Molecular Weight:
174.22
MDL number:

Quality Level

assay

≥95%

form

powder or crystals

storage temp.

2-8°C

Application

cis-Hexamethylphosphetane oxide is a phosphetane oxide-based organocatalyst used for reductive C-N cross couplings.

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Trevor V Nykaza et al.
Journal of the American Chemical Society, 140(45), 15200-15205 (2018-10-30)
A main group-catalyzed method for the synthesis of aryl- and heteroarylamines by intermolecular C-N coupling is reported. The method employs a small-ring organophosphorus-based catalyst (1,2,2,3,4,4-hexamethylphosphetane) and a terminal hydrosilane reductant (phenylsilane) to drive reductive intermolecular coupling of nitro(hetero)arenes with boronic...
Trevor V Nykaza et al.
Angewandte Chemie (International ed. in English), 59(11), 4505-4510 (2019-12-24)
An organocatalytic method for the modular synthesis of diverse N-aryl and N-alkyl azaheterocycles (indoles, oxindoles, benzimidazoles, and quinoxalinediones) is reported. The method employs a small-ring organophosphorus-based catalyst (1,2,2,3,4,4-hexamethylphosphetane P-oxide) and a hydrosilane reductant to drive the conversion of ortho-functionalized nitroarenes...

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