917478

BocA1V1PF2

≥95%

• Synonym(s): (S)-2-((S)-1-((S)-2-((S)-2-((tert-Butoxycarbonyl)amino)propanamido)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-3-(4-fluorophenyl)propanoic acid, AVP ligand, IAP E3 ligase lead for protein degrader research, SNIPER building block
• Empirical Formula (Hill Notation): C₂₈H₄₁FN₄O₇
• Molecular Weight: 564.65
• MDL number: MFCD34549921
• UNSPSC Code: 41116105
• NACRES: NA.22

Properties

• ligand: BocA1V1PF2
• Quality Level: 100
• assay: ≥95%
• form: powder
• reaction suitability: reagent type: ligand
• functional group: carboxylic acid
• storage temp.: 2-8°C
• SMILES string: C[C@H](NC(OC(C)(C)C)=O)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(O)=O)CC2=CC=C(C=C2)F)=O)=O)C(C)(C)C)=O
• InChI: 1S/C28H41FN4O7/c1-16(30-26(39)40-28(5,6)7)22(34)32-21(27(2,3)4)24(36)33-14-8-9-20(33)23(35)31-19(25(37)38)15-17-10-12-18(29)13-11-17/h10-13,16,19-21H,8-9,14-15H2,1-7H3,(H,30,39)(H,31,35)(H,32,34)(H,37,38)/t16-,19-,20-,21+/m0/s1
• InChI key: JVBWBZOMRINKPT-LRGNLBRXSA-N

Description

Application

BocA1V1PF2 is an in silico-derived inhibitor of apoptosis protein (IAP)-recruiting ligand for targeted protein degradation and SNIPER (specific and non-genetic IAP-dependent protein erasers) development, launched in partnership with ComInnex. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight. A C-terminal variant of BocA1V1PF2 is also available as A1V1PF2-OEt (917710).

BocA1V1PF2 conjugates are also available for degrader synthesis. Browse our full synthesis offering here for streamlining SNIPER and PROTAC^® degrader libraries: Degrader Building Blocks
916927 BocA1V1PF2-OC₆-NH₂ hydrochloride
917184 BocA1V1PF2-OC₁₀-NH₂ hydrochloride
917435 BocA1V1PF2-OPEG₁-NH₂ hydrochloride
917680 BocA1V1PF2-OPEG₃-NH₂ hydrochloride

Technology Spotlight: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived Ligands

Other Notes

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)

SNIPERs−Hijacking IAP activity to induce protein degradation

E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable