MilliporeSigma
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918075

Sigma-Aldrich

NanoFabTx Polymer drug formulation kit

PLA mol wt, 100-200 nm particle size, nanoparticles

Synonym(s):
For nanoparticle synthesis for drug delivery

form

nanoparticles

mol wt

PLA

particle size

100-200 nm

application(s)

advanced drug delivery

storage temp.

2-8°C

General description

NanoFabTx formulation kits and lipid mixes enable users to encapsulate a wide variety of therapeutic drug molecules for targeted or extended drug delivery without the need for lengthy trial-and-error optimization. NanoFabTx kits provide an easy to use toolkit for encapsulating a variety of therapeutics in nanoparticles, microparticles, or liposomes. Drug encapsulated particles synthesized with the NanoFabTx kits are suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery and vaccine delivery.

Application

The NanoFabTx Polymer drug formulation kit, PLA, 100-200nm nanoparticles is a ready-to-use nanoformulation kit for nanoparticle synthesis for drug delivery. This kit provides properly selected PLA based formulation materials, and protocols, tested by nanoprecipitation and microfluidic methods, for the facile fabrication of PLA nanoparticles, suitable for pharmaceutical researches and applications.

This kit minimizes laboratory setup with optimized protocols and step-by-step instruction for synthesizing drug-encapsulated nanoparticle-based formulations. Poly(D,L-lactic acid) (PLA) is a biocompatible and biodegradable polymer that has been approved by the FDA for biomedical and pharmaceutical applications. PLA based nanoparticles have been widely used as drug delivery systems for different types of therapeutic molecules, to achieve controlled drug release.
NanoFabTx Polymer drug formulation kit PLA, 100-200nm nanoparticles for nanoparticle synthesis for drug delivery

Features and Benefits

  • Ready-to-use nanoformulation kit for PLA nanoparticles
  • Step-by-step protocols developed and tested by our formulation scientists
  • Flexible synthesis tool to create uniform and reproducible nanoparticles
  • Optimized to make nanoparticles 100–200 nm nanoprecipitation or microfluidics with low polydispersity
  • Based on non-toxic, biodegradable polymers

Comprehensive protocols for two different particle synthesis methods are included:

  • A nanoprecipitation protocol to prepare drug-encapsulated nanoparticles in standard laboratory glassware.
  • A microfliuidics protocol using commercial platforms or syringe pumps.

The microfluidics protocol uses NanoFabTx device kits (911593), which provide all the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

For more information, please refer to the protocol under the document section of this page.

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificate of Analysis

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Certificate of Origin

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Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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