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919446

CCW16-PEG1-BocNH

Synonym(s):

tert-Butyl (2-(2-(4-(4-(N-benzyl-2-chloroacetamido)phenoxy)phenoxy)ethoxy)ethyl)carbamate, Crosslinker-E3 Ligase ligand conjugate, Protein degrader building block for PROTAC® research, RNF4-targeting building block, Template for synthesis of targeted protein degrader

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50 mg

Available to ship TODAYfromMILWAUKEE

$442.00

About This Item

Empirical Formula (Hill Notation):
C30H35ClN2O6
Molecular Weight:
555.06
MDL number:
MFCD34166222
UNSPSC Code:
12352200
NACRES:
NA.22

$442.00

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ligand

CCW16

Quality Level

100

form

liquid

reaction suitability

reactivity: carboxyl reactive, reagent type: ligand-linker conjugate

functional group

amine

storage temp.

2-8°C

SMILES string

O=C(CCl)N(CC1=CC=CC=C1)C2=CC=C(C=C2)OC3=CC=C(OCCOCCNC(OC(C)(C)C)=O)C=C3

InChI

1S/C30H35ClN2O6/c1-30(2,3)39-29(35)32-17-18-36-19-20-37-25-13-15-27(16-14-25)38-26-11-9-24(10-12-26)33(28(34)21-31)22-23-7-5-4-6-8-23/h4-16H,17-22H2,1-3H3,(H,32,35)

InChI key

CLGOHWKKSZYLAH-UHFFFAOYSA-N

Application

Protein degrader building block CCW16-PEG1-BocNH enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a RING finger protein 4 (RNF4)-recruiting ligand, a PEGylated crosslinker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Other Notes

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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This Item
919462919438919411
CCW16-PEG1-BocNH

Sigma-Aldrich

919446

CCW16-PEG1-BocNH

CCW16-PEG5-BocNH ≥95%

Sigma-Aldrich

919462

CCW16-PEG5-BocNH

CCW16-C9-BocNH ≥95%

Sigma-Aldrich

919438

CCW16-C9-BocNH

CCW16-C6-BocNH

Sigma-Aldrich

919411

CCW16-C6-BocNH

reaction suitability

reactivity: carboxyl reactive, reagent type: ligand-linker conjugate

reaction suitability

reactivity: carboxyl reactive, reagent type: ligand-linker conjugate

reaction suitability

reactivity: carboxyl reactive, reagent type: ligand-linker conjugate

reaction suitability

reactivity: carboxyl reactive, reagent type: ligand-linker conjugate

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

form

liquid

form

liquid

form

liquid

form

viscous liquid

ligand

CCW16

ligand

CCW16

ligand

CCW16

ligand

CCW16

functional group

amine

functional group

amine

functional group

amine

functional group

amine

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Articles

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

Carl C Ward et al.
ACS chemical biology, 14(11), 2430-2440 (2019-05-07)
Targeted protein degradation has arisen as a powerful strategy for drug discovery allowing the targeting of undruggable proteins for proteasomal degradation. This approach most often employs heterobifunctional degraders consisting of a protein-targeting ligand linked to an E3 ligase recruiter to
Momar Toure et al.
Angewandte Chemie (International ed. in English), 55(6), 1966-1973 (2016-01-13)
The current inhibitor-based approach to therapeutics has inherent limitations owing to its occupancy-based model: 1) there is a need to maintain high systemic exposure to ensure sufficient in vivo inhibition, 2) high in vivo concentrations bring potential for off-target side effects, and 3) there is
Daniel P Bondeson et al.
Annual review of pharmacology and toxicology, 57, 107-123 (2016-10-13)
Protein homeostasis networks are highly regulated systems responsible for maintaining the health and productivity of cells. Whereas therapeutics have been developed to disrupt protein homeostasis, more recently identified techniques have been used to repurpose homeostatic networks to effect degradation of
View All Related Papers

Global Trade Item Number

SKUGTIN
919446-50MG04065265339070

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