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920401

Sigma-Aldrich

Methoxypolyethylene glycol 1,000 propionic acid

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Synonym(s):
O-(2-Carboxyethyl)-O′-methylpolyethylene glycol 1,000, PEG acid, PEG carboxylic acid, mPEG-COOH, mono-Methyl polyethylene glycol 1′000 propionic acid
Linear Formula:
CH3(OCH2CH2)nOCH2CH2COOH

form

solid

Quality Level

mol wt

average Mn 1,000 (by NMR)

color

white to off-white

Ω-end

(Propionic acid)

α-end

methoxy

polymer architecture

shape: linear
functionality: monofunctional

storage temp.

2-8°C

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This Item
8890885969909289
mol wt

average Mn 1,000 (by NMR)

mol wt

-

mol wt

-

mol wt

PDLA average Mn 55,000 (by NMR), PEG average Mn 5,000 (by NMR)

Ω-end

(Propionic acid)

Ω-end

carboxylic acid

Ω-end

-

Ω-end

-

α-end

methoxy

α-end

methoxy

α-end

-

α-end

-

polymer architecture

shape: linear
functionality: monofunctional

polymer architecture

-

polymer architecture

-

polymer architecture

-

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

Application

Methoxypolyethylene glycol 1,000 propionic acid is a pegylation agent used to conjugate proteins to reduce immunogenicity and prolong serum half-life of proteins and enzymes.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Andrea Fajdetić et al.
European journal of medicinal chemistry, 46(8), 3388-3397 (2011-05-24)
Synthesis, antibacterial activity and pharmacokinetic properties of a novel class of macrolide antibiotics-macrolones-derived from azithromycin, comprising oxygen atom(s) in the linker and either free or esterified quinolone 3-carboxylic group, are reported. Selected compounds showed excellent antibacterial potency towards key erythromycin
A Ton J Dirks et al.
Bioconjugate chemistry, 20(6), 1129-1138 (2009-05-21)
The Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) has recently proven to be a powerful synthetic tool in various fields of chemistry, including protein-polymer conjugation. In this article, we describe a fluorogenic CuAAC, which allows for efficient monitoring of protein-polymer conjugation. We show

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