920568

tert-Butyl 3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)propanoate

• Synonym(s): Rigid linker for PROTAC^® development
• Empirical Formula (Hill Notation): C₁₃H₂₁N₃O₂
• Molecular Weight: 251.32
• MDL number: MFCD34602226
• UNSPSC Code: 12352106
• NACRES: NA.22

Properties

• reaction suitability: reagent type: linker
• Quality Level: 100
• functional group: ester
• storage temp.: 2-8°C
• SMILES string: CC(C)(OC(CCC1=CN=C2CNCCN12)=O)C
• InChI key: OKFDKTIPEQWBHV-UHFFFAOYSA-N

Description

Application

tert-Butyl 3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)propanoate is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
920568
920657
ENAH38A2CCD6
AC5372910424

Other Notes

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable