4-((2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptan-6-yl)oxy)picolinic acid

Name: 4-((2-(<I>tert</I>-Butoxycarbonyl)-2-azaspiro[3.3]heptan-6-yl)oxy)picolinic acid
Brand: ALDRICH
Price: 430 USD
Availability: InStock

Synonym(s):

Rigid linker for PROTAC^® development

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₂₂N₂O₅

Molecular Weight:

334.37

MDL number:

MFCD34602202

UNSPSC Code:

12352106

NACRES:

NA.22

Key Documents

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form

powder

Quality Level

100

reaction suitability

reagent type: linker

functional group

Boc
carboxylic acid

storage temp.

2-8°C

SMILES string

OC(C1=CC(OC2CC3(C2)CN(C(OC(C)(C)C)=O)C3)=CC=N1)=O

InChI

1S/C17H22N2O5/c1-16(2,3)24-15(22)19-9-17(10-19)7-12(8-17)23-11-4-5-18-13(6-11)14(20)21/h4-6,12H,7-10H2,1-3H3,(H,20,21)

InChI key

KRXZLULNVDZBDE-UHFFFAOYSA-N

Related Categories

Chemical Biology

Protein Degrader Building Blocks

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This Item	923265	920622	923400
Sigma-Aldrich 923311 4-((2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptan-6-yl)oxy)picolinic acid	Sigma-Aldrich 923265 4-((7-(tert-Butoxycarbonyl)-7-azaspiro[3.5]nonan-2-yl)oxy)picolinic acid	Sigma-Aldrich 920622 4-(2-(tert-Butoxycarbonyl)-5-oxo-2,6-diazaspiro[3.6]decan-6-yl)picolinic acid	Sigma-Aldrich 923400 4-((7-(tert-Butoxycarbonyl)-7-azaspiro[3.5]nonan-2-yl)oxy)benzoic acid
reaction suitability reagent type: linker	reaction suitability reagent type: linker	reaction suitability reagent type: linker	reaction suitability reagent type: linker
functional group Boc, carboxylic acid	functional group Boc, carboxylic acid	functional group Boc, carboxylic acid	functional group Boc, carboxylic acid
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
form powder	form powder	form powder	form powder or crystals

Application

4-((2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptan-6-yl)oxy)picolinic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
923338
923370
923419
923346
923427

Other Notes

Protein Degrader Building Blocks

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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