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924474

Sigma-Aldrich

Hyaluronic Acid

Low Viscosity, Low endotoxin

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Synonym(s):
3D bioprinting, HA, Hyaluronan

Quality Level

form

(powder or chunk(s) or fibers)

impurities

<10 CFU/g Bioburden
<100 EU/g Endotoxin

color

white to off-white

suitability

conforms to structure for NMR

storage temp.

2-8°C

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This Item
H0161924490914568
vibrant-m

924474

Hyaluronic Acid

vibrant-m

924490

Hyaluronic acid methacrylate

vibrant-m

914568

Hyaluronic acid methacrylate

form

(powder or chunk(s) or fibers)

form

lyophilized powder

form

(Solid chunks, fibers or powder)

form

powder or chunks (or fibers)

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

impurities

<10 CFU/g Bioburden, <100 EU/g Endotoxin

impurities

-

impurities

≤10 CFU/g Bioburden (Fungal), ≤10 CFU/g Bioburden (Total Aerobic), 100 EU/g Endotoxin

impurities

-

color

white to off-white

color

-

color

white to pale yellow

color

white to off-white

suitability

conforms to structure for NMR

suitability

-

suitability

-

suitability

-

General description

Hyaluronic acid (HA) is a linear polysaccharide of alternating D-glucuronic acid, and N-acetyl-D-glucosamine found in the extracellular matrix. HA is commonly chemically modified to form covalently crosslinked hydrogels. Other properties of HA include cell surface receptors CD44 and RHAMM recognition and degradation via hyaluronidases.

Application

HA is increasingly used for the following biomedical applications:
  • Cell migration
  • Angiogenesis
  • Viability
  • Proliferation

Our low endotoxin HA is tested for both endotoxin (< 100 EU/g) and bioburden (< 10 CFU/g) levels, so you can choose which material is right for your research.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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T1503
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25G
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705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

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Tracey J Brown
Current pharmaceutical biotechnology, 9(4), 253-260 (2008-08-12)
Despite advances in chemotherapeutic regimens, the treatment of metastatic cancer remains a challenge. A key problem with chemotherapy drugs is nonspecific drug distribution, resulting in low tumor concentrations and systemic toxicity. The holy grail of clinical cancer research has been
Federica Camin et al.
Journal of agricultural and food chemistry, 58(1), 570-577 (2009-12-17)
H, C, and O stable isotope ratios and the elemental profile of 267 olive oils and 314 surface waters collected from 8 European sites are presented and discussed. The aim of the study was to investigate if olive oils produced
Xian Xu et al.
Soft matter, 8(12), 3280-3294 (2012-03-16)
Hyaluronic acid (HA) is one of nature's most versatile and fascinating macromolecules. Being an essential component of the natural extracellular matrix (ECM), HA plays an important role in a variety of biological processes. Inherently biocompatible, biodegradable and non-immunogenic, HA is
Kevin T Dicker et al.
Acta biomaterialia, 10(4), 1558-1570 (2013-12-24)
Hyaluronan (HA) is a linear polysaccharide with disaccharide repeats of d-glucuronic acid and N-acetyl-d-glucosamine. It is evolutionarily conserved and abundantly expressed in the extracellular matrix (ECM), on the cell surface and even inside cells. Being a simple polysaccharide, HA exhibits
Jason A Burdick et al.
Advanced materials (Deerfield Beach, Fla.), 23(12), H41-H56 (2011-03-12)
Hyaluronic acid (HA), an immunoneutral polysaccharide that is ubiquitous in the human body, is crucial for many cellular and tissue functions and has been in clinical use for over thirty years. When chemically modified, HA can be transformed into many

Articles

Engineered ECMs enhance immune therapy in cancer treatment by supporting cells and tissues and modulating immune response. They improve immune cell maturation, expansion, and regulation through biomaterial manipulation, acting as frameworks or carriers for enhanced tumor immunotherapy.

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