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Methacrylated Alginate

Medium Viscosity, Low endotoxin

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Synonym(s):
3D Bioprinting, AlMA, AlgMA, Alginate, Methacrylate, Sodium Alginate

description

Degree of Substitution: 15-25%

Quality Level

form

(Powder or chunk(s) or fibers)

impurities

<10 CFU/g Bioburden (Aerobic)
<10 CFU/g Bioburden (Fungal)
<100 EU/g Endotoxin

color

white to off-white

suitability

conforms to structure for NMR

Related Categories

Application

This product is a low endotoxin version alginate methacrylate ready to be used in biomedical applications.
Alginate is an anionic polysaccharide that is widely used in pharmaceutical and biomedical applications due to its non-animal origin, low toxicity, biocompatibility, and biodegradability. Alginate hydrogels are commonly used to fabricate tissue engineering scaffolds, bioinks for 3D bioprinting, and nanocarriers for drug & gene delivery. Due to the thermal or photochemical crosslinking of the terminal methacrylates, methacrylate-functionalized alginate can be used to prepare hydrogels resistant to matrix degradation. Properties of the resulting hydrogel (e.g., stiffness, swelling ratio, rate of degradation) can be tuned by alginate molecular weight, degree of methacrylate functionalization, and crosslink density.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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K A Smeds et al.
Journal of biomedical materials research, 54(1), 115-121 (2000-11-15)
In situ photopolymerization is an exciting new technique for tissue engineering. Two photocrosslinkable polysaccharides composed of alginate and hyaluronan are described that upon photolysis form soft, flexible, and viscoelastic hydrogels. The degree of methacrylate modification and thus covalent affects mechanical
Siddhesh N Pawar et al.
Biomaterials, 33(11), 3279-3305 (2012-01-28)
Alginates have become an extremely important family of polysaccharides because of their utility in preparing hydrogels at mild pH and temperature conditions, suitable for sensitive biomolecules like proteins and nucleic acids, and even for living cells such as islets of
Oju Jeon et al.
Biomaterials, 30(14), 2724-2734 (2009-02-10)
Photocrosslinked and biodegradable alginate hydrogels were engineered for biomedical applications. Photocrosslinkable alginate macromers were prepared by reacting sodium alginate and 2-aminoethyl methacrylate in the presence of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride and N-hydroxysuccinimide. Methacrylated alginates were photocrosslinked using ultraviolet light with 0.05% photoinitiator.
Jia Jia et al.
Acta biomaterialia, 10(10), 4323-4331 (2014-07-08)
Recent advances in three-dimensional (3-D) printing offer an excellent opportunity to address critical challenges faced by current tissue engineering approaches. Alginate hydrogels have been used extensively as bioinks for 3-D bioprinting. However, most previous research has focused on native alginates
Eneko Axpe et al.
International journal of molecular sciences, 17(12) (2016-11-30)
Three-dimensional (3D) bioprinting is on the cusp of permitting the direct fabrication of artificial living tissue. Multicellular building blocks (bioinks) are dispensed layer by layer and scaled for the target construct. However, only a few materials are able to fulfill

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