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924482

Methacrylated Alginate

Medium Viscosity, Low endotoxin

Synonym(s):

3D Bioprinting, AlMA, AlgMA, Alginate, Methacrylate, Sodium Alginate, Alginate / Alginic acid

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Pack SizeSKUAvailabilityPrice
500 mg
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$331.00

About This Item

NACRES:
NA.23
UNSPSC Code:
12162002

$331.00


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description

Degree of Substitution: 15-25%

Quality Level

form

(Powder or chunk(s) or fibers)

impurities

<10 CFU/g Bioburden (Aerobic), <10 CFU/g Bioburden (Fungal), <100 EU/g Endotoxin

color

white to off-white

suitability

conforms to structure for NMR

Application

This product is a low endotoxin version alginate methacrylate ready to be used in biomedical applications.
Alginate is an anionic polysaccharide that is widely used in pharmaceutical and biomedical applications due to its non-animal origin, low toxicity, biocompatibility, and biodegradability[1]. Alginate hydrogels are commonly used to fabricate tissue engineering scaffolds[2], bioinks for 3D bioprinting[3][4], and nanocarriers for drug & gene delivery. Due to the thermal or photochemical crosslinking of the terminal methacrylates, methacrylate-functionalized alginate can be used to prepare hydrogels resistant to matrix degradation[5][6][7][8]. Properties of the resulting hydrogel (e.g., stiffness, swelling ratio, rate of degradation) can be tuned by alginate molecular weight, degree of methacrylate functionalization, and crosslink density.

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This Item
913057921610920983
form

(Powder or chunk(s) or fibers)

form

(Powder or chunk(s) or fibers)

form

viscous liquid (or gel)

form

viscous liquid (or gel)

suitability

conforms to structure for NMR

suitability

conforms to structure for NMR

suitability

-

suitability

-

description

Degree of Substitution: 15-25%

description

-

description

suitable for 3D bioprinting applications

description

suitable for 3D bioprinting applications

impurities

<10 CFU/g Bioburden (Aerobic), <100 EU/g Endotoxin, <10 CFU/g Bioburden (Fungal)

impurities

-

impurities

≤5 CFU/g Bioburden (Fungal), ≤5 CFU/g Bioburden (Total Aerobic)

impurities

<5 CFU/g Bioburden

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

color

white to off-white

color

light yellow

color

colorless to pale yellow

color

colorless to pale yellow


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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K A Smeds et al.
Journal of biomedical materials research, 54(1), 115-121 (2000-11-15)
In situ photopolymerization is an exciting new technique for tissue engineering. Two photocrosslinkable polysaccharides composed of alginate and hyaluronan are described that upon photolysis form soft, flexible, and viscoelastic hydrogels. The degree of methacrylate modification and thus covalent affects mechanical
Siddhesh N Pawar et al.
Biomaterials, 33(11), 3279-3305 (2012-01-28)
Alginates have become an extremely important family of polysaccharides because of their utility in preparing hydrogels at mild pH and temperature conditions, suitable for sensitive biomolecules like proteins and nucleic acids, and even for living cells such as islets of
Oju Jeon et al.
Biomaterials, 30(14), 2724-2734 (2009-02-10)
Photocrosslinked and biodegradable alginate hydrogels were engineered for biomedical applications. Photocrosslinkable alginate macromers were prepared by reacting sodium alginate and 2-aminoethyl methacrylate in the presence of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride and N-hydroxysuccinimide. Methacrylated alginates were photocrosslinked using ultraviolet light with 0.05% photoinitiator.



Global Trade Item Number

SKUGTIN
924482-500MG04065267321981

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