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NanoFabTX- NH2 Lipid Mix

for synthesis of amine functionalized liposomes

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Synonym(s):
Liposome, Liposome synthesis kit, Microfluidics, NanoFabTx liposome reagent kit, Small molecule drug formulation kit, for small molecule drug delivery

description

NanoFabTx Amine-functionalized liposome kit for small molecule encapsulation

Quality Level

application(s)

advanced drug delivery

storage temp.

−20°C

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This Item
911860909637911593
description

NanoFabTx Amine-functionalized liposome kit for small molecule encapsulation

description

Microfludic device kit for synthesizing 1-5 μm microparticles

Kit components :

  • Microfluidic chip x 1
  • Tubings and accessories

description

PLGA nanoparticle screening kit for synthesis of 100 and 200 nm particles

description

Microfludic device kit for synthesizing nanparticles

Kit components :

  • Microfluidic chip x 1
  • Tubings and accessories

application(s)

advanced drug delivery

application(s)

advanced drug delivery

application(s)

advanced drug delivery

application(s)

advanced drug delivery

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

General description

NanoFabTX- NH2 Lipid Mix; for synthesis of amine functionalized liposomes is a ready-to-use nanoformulation lipid blend that includes lyophilized lipids and step-by-step instructions for synthesizing amine functionalized liposomes for small molecule drug delivery applications. Lipid-based formulations are widely used for drug delivery and enable improved therapeutic efficacy of a range of drug types including small molecules, nucleic acids, proteins and peptides. The amine functionalized surface group allows for facile conjugation of targeting groups onto the liposome surface for targeted drug delivery.

Application

About NanoFabTx

NanoFabTx is a collection of ready-to-use drug formulation kits, lipid mixes, and microfluidic device kits for the synthesis of nanocarriers and microcarriers for drug delivery. The kits enable users to encapsulate a wide variety of therapeutic drug molecules for targeted or extended drug delivery without the need for lenghty trial-and-error optimization. NanoFabTx provide an easy to use toolkit for encapsulating a variety of therapeutics in nanoparticles, microparticles, or liposomes. Drug encapsulated particles synthesized with the NanoFabTx kits are suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery, and vaccine delive

Features and Benefits

  • A ready-to-use nanoformulation lipid blend for the synthesis of amine functionalized liposomes
  • Step-by-step protocols (extrusion and microfluidics) developed and tested by our formulation scientists
  • Flexible synthesis tool to create uniform and reproducible liposomes
  • Optimized to make liposomes around 100 nm with low polydispersity
  • Amine surface functionalization allows for targeting ligand conjugation to enable targeted drug delivery
The NanoFabTX-NH2 Lipid Mix provides lipid blends and protocols for extrusion and microfluidics to synthesize liposomes for drug delivery research application. This lipid mix can be combined with the NanoFabTx Microfluidic - nano device kit (Cat.No. 911593) for microfluidic synthesis of amine functionalized liposomes. Comprehensive protocols for liposome synthesis are included:
  • A lipid film hydration and extrusion protocol
  • A microfluidics protocol using commercial platforms or syringe pumps
The microfluidics protocol included with this product uses the NanoFabTx device kit (911593). These kits come with the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3


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Which polymers can make nanoparticulate drug carriers long-circulating?
Torchilin V P, et al.
Advanced Drug Delivery Reviews, 16, 141-155 (1995)
Daryl C Drummond et al.
Cancer research, 66(6), 3271-3277 (2006-03-17)
Liposome formulations of camptothecins have been actively pursued because of the potential for significant pharmacologic advantages from successful drug delivery of this important class of anticancer drugs. We describe nanoliposomal CPT-11, a novel nanoparticle/liposome construct containing CPT-11 (irinotecan) with unprecedented
L D Mayer et al.
Biochimica et biophysica acta, 1025(2), 143-151 (1990-06-27)
Studies from this laboratory (Mayer et al. (1986) Biochim. Biophys. Acta 857, 123-126) have shown that doxorubicin can be accumulated into liposomal systems in response to transmembrane pH gradients (inside acidic). Here, detailed characterizations of the drug uptake and retention
Yunes Panahi et al.
Artificial cells, nanomedicine, and biotechnology, 45(4), 788-799 (2017-03-11)
Liposome is a new nanostructure for the encapsulation and delivery of bioactive agents. There are a lot of bioactive materials that could be incorporated into liposomes including cosmetics, food ingredients, and pharmaceuticals. Liposomes possess particular properties such as biocompatibility, biodegradability;
A L Klibanov et al.
FEBS letters, 268(1), 235-237 (1990-07-30)
Incorporation of dioleoyl N-(monomethoxy polyethyleneglycol succinyl)phosphatidylethanolamine (PEG-PE) into large unilamellar liposomes composed of egg phosphatidylcholine:cholesterol (1:1) does not significantly increase the content leakage when the liposomes are exposed to 90% human serum at 37 degrees C, yet the liposomes show

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