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4,6-Dimethyl-2-(methylsulfinyl)-3-nitropyridine

Name: 4,6-Dimethyl-2-(methylsulfinyl)-3-nitropyridine
Brand: ALDRICH

Synonym(s):

2-Sulfonylpyridine, Cysteine-reactive electrophile, S_NAr probe

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About This Item

Empirical Formula (Hill Notation):

C₈H₁₀N₂O₃S

CAS Number:

2429964-95-2

Molecular Weight:

214.24

MDL number:

MFCD16251316

NACRES:

NA.22

UNSPSC Code:

12352200

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Properties

reaction suitability

reagent type: chemical modification reagent

Quality Level

100

storage temp.

2-8°C

Description

Application

4,6-Dimethyl-2-(methylsulfinyl)-3-nitropyridine is a sulfoxide-containing fragment for covalent ligand discovery via cysteine labeling as demonstrated by Zamboldo and coworkers. Fragment electrophiles are useful in chemoproteomic and ligandability studies for both traditionally druggable proteins as well as ″undruggable,″ or difficult-to-target, proteins.

Related useful products may include cysteine fragment KB02 (912131), IA alkyne (924237), IA 5-TAMRA (925020), desthiobiotin iodoacetamide (923826), or biotin iodoacetamide (B2059).

Other Notes

2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles

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This Item	923818	911798	404365
Sigma-Aldrich 925136 4,6-Dimethyl-2-(methylsulfinyl)-3-nitropyridine	Sigma-Aldrich 923818 N-(But-3-yn-1-yl)-2-(((2-oxo-2H-chromen-7-yl)oxy)methyl)acrylamide	Sigma-Aldrich 911798 N-(4-Bromophenyl)-N-phenylacrylamide	Sigma-Aldrich 404365 Procion^® Red MX-5B
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 200
reaction suitability reagent type: chemical modification reagent	reaction suitability reagent type: chemical modification reagent reaction type: click chemistry	reaction suitability -	reaction suitability -
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. room temp

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles.

Claudio Zambaldo et al.

Journal of the American Chemical Society, 142(19), 8972-8979 (2020-04-18)

The emerging use of covalent ligands as chemical probes and drugs would benefit from an expanded repertoire of cysteine-reactive electrophiles for efficient and diverse targeting of the proteome. Here we use the endogenous electrophile sensor of mammalian cells, the KEAP1-NRF2

Global Trade Item Number

SKU	GTIN
925136-50MG	04065267468662
925136-100MG	04065267468655

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