- 925217
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925217
TissueFab® - low endotoxin GelMA-UV bioink
0.2 μm filtered, suitable for 3D bioprinting applications
All Photos(1)
Synonym(s):
Bioink, GelMA, Gelatin methacrylamide, Gelatin methacrylate, Gelatin methacryloyl
Quality Level
sterility
0.2 μm filtered
form
viscous liquid (to gel)
size
10 mL
impurities
≤5 CFU/g Bioburden
≤5 CFU/g Bioburden (Aerobic)
≤50 EU/mL Endotoxin
color
pale yellow to colorless
pH
6.5-7.5
viscosity
2-20 cP
application(s)
3D bioprinting
storage temp.
2-8°C
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This Item | E6779 | 810682 | 810683 |
|---|---|---|---|
| sterility 0.2 μm filtered | sterility - | sterility - | sterility - |
| form viscous liquid (to gel) | form - | form lyophilized powder | form lyophilized powder |
| size 10 mL | size - | size - | size - |
| impurities ≤5 CFU/g Bioburden | impurities - | impurities Tested for IgG | impurities Tested for IgG |
| color pale yellow to colorless | color - | color - | color - |
| pH 6.5-7.5 | pH - | pH 6.8-7.2 | pH 6.8-7.2 |
General description
Gelatin methacryloyl (GelMA) is a polymerizable hydrogel material derived from natural extracellular matrix (ECM) components. Due to its low cost, abundance, and retention of natural cell binding motifs, gelatin has become a highly sought material for tissue engineering applications.
The addition of photocrosslinkable methacrylamide functional groups in GelMA allows the synthesis of biocompatible, biodegradable, and non-immunogenic hydrogels that are stable in biologically relevant conditions and promote cell adhesion, spreading, and proliferation.
Temporal and spatial control of the crosslinking reaction can be obtained by adjusting the degree of functionalization and polymerization conditions, allowing for the fabrication of hydrogels with unique patterns, 3D structures, and morphologies.
The addition of photocrosslinkable methacrylamide functional groups in GelMA allows the synthesis of biocompatible, biodegradable, and non-immunogenic hydrogels that are stable in biologically relevant conditions and promote cell adhesion, spreading, and proliferation.
Temporal and spatial control of the crosslinking reaction can be obtained by adjusting the degree of functionalization and polymerization conditions, allowing for the fabrication of hydrogels with unique patterns, 3D structures, and morphologies.
Application
Gelatin methacrylate based bioinks have been used in the following bioprinting applications:
- osteogenic,
- chondrogenic ,
- hepatic ,
- adipogenic ,
- vasculogenic ,
- epithelial ,
- endothelial ,
- cardiac valve ,
- skin ,
- tumors
Features and Benefits
- Ready-to-use formulation optimized for high printing fidelity and cell viability, eliminating the lengthy bioink formulation development process
- Step-by-step protocols developed and tested by MilliporeSigma 3D Bioprinting Scientists, no prior 3D bioprinting experience neede
- Suitable for different extrusion-based 3D bioprinter model
- Methacrylamide functional group can also be used to control the hydrogel physical parameters such as pore size, degradation rate, and swell ratio.
Legal Information
TISSUEFAB is a registered trademark of Sigma-Aldrich Co. LLC
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Certificate of Analysis
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Certificate of Origin
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Protocol
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