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933597

Sigma-Aldrich

Poly(Guluronate)

low endotoxin

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Synonym(s):
Alginate, Bioink, Bioprinting, Guluronic Acid, Hydrogel, Ionic, Sodium Alginate
Linear Formula:
(C6H8O6)n

description

GPC 5-15 kDa

Quality Level

form

(Solid chunks, fibres or powder)

impurities

<125 EU/g Endotoxin
<5 CFU/g Bioburden(Total aerobic)
<5 CFU/g Bioburden(fungal)

color

white to off-white

storage temp.

2-8°C

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This Item
912387924474180947
Poly(Guluronate) low endotoxin

Sigma-Aldrich

933597

Poly(Guluronate)

Alginate methacrylate high viscosity, degree of methacrylation: 20-40%

Sigma-Aldrich

912387

Alginate methacrylate

Sigma-Aldrich

Sigma-Aldrich

924474

Hyaluronic Acid

impurities

<125 EU/g Endotoxin, <5 CFU/g Bioburden(Total aerobic), <5 CFU/g Bioburden(fungal)

impurities

-

impurities

<10 CFU/g Bioburden, <100 EU/g Endotoxin

impurities

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

description

GPC 5-15 kDa

description

degree of functionalization: 20-40%

description

-

description

-

color

white to off-white

color

light yellow

color

white to off-white

color

-

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-

General description

Sodium alginate is a natural linear polysaccharide derived from brown algae made up of blocks of B-D-mannuronate (M) and a-L-guluronate (G). Guluronate blocks that bind Ca2+ cations to form ionic bonds. Poly(guluronate) is isolated from alginate which can be used alone as a stabilizer or further modified to create additional functional groups.

Application

Sodium Alginate based hydrogels are widely used in tissue engineering, 3D bioprinting, and drug delivery applications.

Features and Benefits

  • Sterile, low endotoxin
  • Batch control offers reproducible models for preclinical toxicology testing and drug screening
  • Extended shelf-life & stability

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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25G
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K Y Lee et al.
Journal of biomedical materials research, 56(2), 228-233 (2001-05-08)
Degradable and injectable hydrogels may be ideal for bone-tissue engineering, especially in the craniofacial region because of the ease of access for injection. Alginate hydrogels potentially could be used as injectable cell delivery vehicles, but they exhibit a limited range
Kuen Yong Lee et al.
Biomaterials, 25(13), 2461-2466 (2004-01-31)
Hydrogels, chemically cross-linked or physically entangled, have found a number of applications as novel delivery vehicles of drugs and cells. However, the narrow ranges of degradation rates and mechanical strength currently available from many hydrogels limits their applications. We have
K H Bouhadir et al.
Journal of pharmaceutical sciences, 89(7), 910-919 (2000-06-22)
We have incorporated daunomycin, an antineoplastic agent, into a biodegradable hydrogel through a labile covalent bond. In brief, sodium alginate was chemically broken down to low molecular weight and followed by oxidation to prepare poly(aldehyde guluronate). Adipic dihydrazide was used
David Leal et al.
Carbohydrate polymers, 92(1), 157-166 (2012-12-12)
Graft copolymers were prepared by formation of an amide bond between poly-α-L-guluronic acid (MW 24,000), isolated from sodium alginate and the free amino group of PNIPAAm-NH(2). SEM micrographs revealed the formation of a macroscopic network on the surface of the

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