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Sigma-Aldrich

Ovine collagen

new

maleimide functionalized, low endotoxin

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Synonym(s):
CollOvine-PEG2-MAL
CAS Number:

form

lyophilized powder

Quality Level

impurities

Bioburden, none detected
low endotoxin
≤0.1 EU/mg Endotoxin

color

white to off-white

functional group

maleimide

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General description

Collagen is a major component of the extracellular matrix (ECM) and offers low immunogenicity, a porous structure, good permeability, and biocompatibility to promote cell viability, adhesion, spreading, proliferation and differentiation.

Low endotoxin maleimide functionalized collagen derived from ovine has many biomedical applications and is a great alternative to other naturally derived materials such as those derived from bovine or porcine. Maleimide conjugations are commonly used to generate covalent conjugates with sulfhydryl containing molecules. This thiol-maleimide click chemistry reaction is commonly used for bioconjugation given its reliability, efficiency, selectivity, and preferential chemical reaction at neutral pH. The PEGylated maleimide functionalization provides methods for easy bioconjugation while maintain the advantages of the naturally derived collagen.

Application

  • 3D bioprinting
  • Tissue engineering
  • Drug delivery
  • Regenerative medicine
  • Cell culture, encapsulation, expansion and differentiation

Features and Benefits

  • Certified Disease Free Sheep
  • 93-97% Type I Collagen
  • 3-7% Type III Collagen
  • 99% Purity
  • Prion Free

Legal Information

CollOvine is a trademark of OviGenex LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Collagen as Bioink for Bioprinting: A Comprehensive Review
Osidak O E, et al.
International Journal of Bioprinting, 6(3), 270-270 (2020)
Elizabeth E Antoine et al.
Tissue engineering. Part B, Reviews, 20(6), 683-696 (2014-06-14)
Type I collagen hydrogels have been used successfully as three-dimensional substrates for cell culture and have shown promise as scaffolds for engineered tissues and tumors. A critical step in the development of collagen hydrogels as viable tissue mimics is quantitative
Atiqah Salleh et al.
Biomedicines, 10(4), 816-816 (2022-04-24)
Tissue engineering products have grown rapidly as an alternative solution available for chronic wound and burn treatment. However, some drawbacks include additional procedures and a lack of antibacterial properties that can impair wound healing, which are issues that need to
Jana Stepanovska et al.
Biomedicines, 9(9), 1137-1137 (2021-09-29)
Bioprinting is a modern tool suitable for creating cell scaffolds and tissue or organ carriers from polymers that mimic tissue properties and create a natural environment for cell development. A wide range of polymers, both natural and synthetic, are used

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