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MilliporeSigma

934372

Sigma-Aldrich

MC-Val-Cit-PAB-PNP

≥95%

Synonym(s):

L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-

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About This Item

Empirical Formula (Hill Notation):
C35H43N7O11
CAS Number:
Molecular Weight:
737.76
Beilstein/REAXYS Number:
10322169
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.22

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Quality Level

assay

≥95%

form

powder

storage temp.

2-8°C

SMILES string

[N+](=O)([O-])c1ccc(cc1)OC(=O)OCc2ccc(cc2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCCCCN3C(=O)C=CC3=O)C(C)C)CCCNC(=O)N

InChI key

HYSPJPGXSALJRR-DHIFEGFHSA-N

Application

This is a bifunctional cathepsin cleavable linker used in the construction of antibody drug conjugates (ADC).

Features and Benefits

The maleimide functionality can be used for bioconjugation to thiols in monoclonal antibodies while the activated carbonate esters can be used for construction of carbamate linkages with amine containing payloads.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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