A8309

Sigma-Aldrich

Acethydrazide

90%

Synonym(s):
Acetylhydrazine, Acetic acid hydrazide
Linear Formula:
CH3CONHNH2
CAS Number:
Molecular Weight:
74.08
Beilstein/REAXYS Number:
506165
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

90%

impurities

<10% acetic acid

bp

129 °C/18 mmHg (lit.)

mp

58-68 °C (lit.)

SMILES string

CC(=O)NN

InChI

1S/C2H6N2O/c1-2(5)4-3/h3H2,1H3,(H,4,5)

InChI key

OFLXLNCGODUUOT-UHFFFAOYSA-N

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Application

Acethydrazide can be used in the synthesis of (E)-N′-(2-hydroxybenzylidene)acetohydrazide, an ONO pincer ligand.

Packaging

5, 25, 100 g in glass bottle

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

UN 2811 6.1 / PGIII

WGK Germany

WGK 1

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Certificate of Analysis

Certificate of Origin

Analysis of isoniazid, acetylhydrazine and [15N2]acetylhydrazine in serum by capillary gas chromatography-ammonia chemical ionization mass spectrometry.
G Karlaganis et al.
Journal of chromatography, 420(1), 171-177 (1987-09-04)
A Walubo et al.
Methods and findings in experimental and clinical pharmacology, 20(8), 649-655 (1999-01-29)
Isoniazid and its metabolites acetylisoniazid, hydrazine and monoacetylhydrazine were investigated for generation of oxygen free radicals during incubation with rat liver slices. Lipid peroxidation was assessed by the thiobarbituric acid reactive substances test using malonaldehyde as the external standard, while...
Determination of the isoniazid metabolite monoacetylhydrazine in urine by high-performance liquid chromatography.
P J Jenner et al.
Journal of chromatography, 415(1), 188-196 (1987-03-20)
T C Sarich et al.
Archives of toxicology, 70(12), 835-840 (1996-01-01)
Isoniazid (INH) continues to be a highly effective drug in the chemoprophylaxis and treatment of tuberculosis; however, its use is associated with hepatotoxicity (predominantly hepatic necrosis) in 1-2% of individuals. The INH metabolites, acetylhydrazine and hydrazine, have each been implicated...
Shahrzad Tafazoli et al.
Toxicology and applied pharmacology, 229(1), 94-101 (2008-02-26)
Isoniazid is an anti-tuberculosis drug that can cause hepatotoxicity in 20% of patients that is usually associated with an inflammatory response. Hepatocytes when exposed to non-toxic levels of H2O2, to simulate H2O2 formation by inflammatory cells, became twice as sensitive...

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