Analysis of isoniazid, acetylhydrazine and [15N2]acetylhydrazine in serum by capillary gas chromatography-ammonia chemical ionization mass spectrometry.
G Karlaganis et al.
Journal of chromatography, 420(1), 171-177 (1987-09-04)
A Walubo et al.
Methods and findings in experimental and clinical pharmacology, 20(8), 649-655 (1999-01-29)
Isoniazid and its metabolites acetylisoniazid, hydrazine and monoacetylhydrazine were investigated for generation of oxygen free radicals during incubation with rat liver slices. Lipid peroxidation was assessed by the thiobarbituric acid reactive substances test using malonaldehyde as the external standard, while...
Determination of the isoniazid metabolite monoacetylhydrazine in urine by high-performance liquid chromatography.
P J Jenner et al.
Journal of chromatography, 415(1), 188-196 (1987-03-20)
T C Sarich et al.
Archives of toxicology, 70(12), 835-840 (1996-01-01)
Isoniazid (INH) continues to be a highly effective drug in the chemoprophylaxis and treatment of tuberculosis; however, its use is associated with hepatotoxicity (predominantly hepatic necrosis) in 1-2% of individuals. The INH metabolites, acetylhydrazine and hydrazine, have each been implicated...
Shahrzad Tafazoli et al.
Toxicology and applied pharmacology, 229(1), 94-101 (2008-02-26)
Isoniazid is an anti-tuberculosis drug that can cause hepatotoxicity in 20% of patients that is usually associated with an inflammatory response. Hepatocytes when exposed to non-toxic levels of H2O2, to simulate H2O2 formation by inflammatory cells, became twice as sensitive...