Etidronic acid

60% aqueous solution

OEDFK, HDEPA, HEDP, 1-Hydroxyethane-1,1,-diphosphonic acid, 1-Hydroxyethylidenediphosphonic acid
Linear Formula:
CAS Number:
Molecular Weight:
Beilstein/REAXYS Number:
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PubChem Substance ID:
Pricing and availability is not currently available.

Quality Level


suitable for photographic applications

SMILES string




InChI key



Etidronic acid (HEBP) can be employed as a catalyst for the synthesis of:
  • 5-Nitro-3,4-dihydropyrimidin-2(1H)-ones through the reaction between 1-(2-hydroxyphenyl)-2-nitroethanone, aryl aldehydes and urea via one-pot cyclo condensation reaction.
  • Thiiranes from epoxides and ammonium thiocyanate.


100, 500 g in poly bottle

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. H6773.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.



Signal Word


Hazard Statements

Precautionary Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


UN3265 - class 8 - PG 3 - EHS - Corrosive liquid, acidic, organic, n.o.s., HI: all

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Om Alkhir Alshanta et al.
Antibiotics (Basel, Switzerland), 9(9) (2020-09-26)
Endodontic infections are often interkingdom biofilms, though current clinical management rarely considers this phenomenon. This study aimed to evaluate new and standard endodontic antimicrobial regimens against simple and complex Candida albicans and Enterococcus faecalis mono- and dual-species biofilms. C. albicans...
Etidronic acid: a new and efficient catalyst for the synthesis of novel 5-nitro-3, 4-dihydropyrimidin-2 (1H)-ones
Savant MM, et al.
Catalysis Letters, 132(1-2), 281-284 (2009)
Siyoung Kim et al.
European journal of pharmacology, 699(1-3), 14-22 (2012-12-04)
Nitrogen-containing bisphosphonates (NBPs) have greater anti-bone-resorptive effects than non-nitrogen-containing bisphosphonates (non-NBPs). Hence, NBPs are the current first-choice drug for osteoporosis. However, NBPs carry a risk of osteonecrosis of jaws. Some animal and human studies suggest that non-NBPs may have anti-bone-resorptive...
Ippei Suzuki et al.
Chemical & pharmaceutical bulletin, 64(12), 1713-1719 (2016-12-03)
A rapid, sensitive, and specific analytical method for the determination of 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) on uncooked foods after treatment with a peracetic acid-based sanitizer (PAS) was developed. The method involves simple sample preparation steps and analysis using ion chromatography (IC)...
Facile conversion of epoxides to thiiranes with ammonium thiocyanate catalyzed with etidronic acid
Wu L, et al.
Bulletin of the Korean Chemical Society,, 31(5), 1419-1420 (2010)

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