Secondary organic material formed by methylglyoxal in aqueous aerosol mimics.
Sareen N, et al.
Atmospheric Chemistry and Physics, 10(3) (2010)
Björn Kuhla et al.
Annals of the New York Academy of Sciences, 1043, 211-216 (2005-07-23)
The accumulation of advanced glycation end products (AGEs) in brains with Alzheimer's disease (AD) has been implicated in the formation of insoluble deposits such as amyloid plaques and neurofibrillary tangles. AGEs are also known to activate glia, resulting in inflammation...
Weijing Cai et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(13), 4940-4945 (2014-02-26)
Age-associated dementia and Alzheimer's disease (AD) are currently epidemic. Neither their cause nor connection to the metabolic syndrome (MS) is clear. Suppression of deacetylase survival factor sirtuin 1 (SIRT1), a key host defense, is a central feature of AD. Age-related...
Xiao-Yan Zou et al.
The Journal of investigative dermatology, 135(2), 589-598 (2014-09-04)
Glyoxalase I (GLO1) is a methylglyoxal detoxification enzyme being implicated in the progression of multiple malignancies. However, currently, the role of GLO1 in human nonmelanoma skin tumors remains unclear. To explore the expression of GLO1 in cutaneous neoplasms and its...
Georg T Wondrak et al.
Biochemical pharmacology, 63(3), 361-373 (2002-02-21)
Tissue deterioration and aging have long been associated with the accumulation of chemically induced protein and DNA damage. Reactive oxygen species (ROS) and reactive carbonyl species (RCS), especially alpha-dicarbonyl compounds, are key mediators of damage caused by oxidative stress, glycation...