A59654

5-Aminoindole

Name: 5-Aminoindole
Brand: ALDRICH
Price: 21.37 USD
Availability: InStock

97%

Synonym(s):

5-Indolamine, NSC 61452

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About This Item

Empirical Formula (Hill Notation):

C₈H₈N₂

CAS Number:

5192-03-0

Molecular Weight:

132.16

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24891044

EC Number:

225-977-2

Beilstein/REAXYS Number:

112348

MDL number:

MFCD00005679

Assay:

97%

Form:

crystals

Key Documents

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InChI key

ZCBIFHNDZBSCEP-UHFFFAOYSA-N

InChI

1S/C8H8N2/c9-7-1-2-8-6(5-7)3-4-10-8/h1-5,10H,9H2

SMILES string

Nc1ccc2[nH]ccc2c1

assay

97%

form

crystals

mp

131-133 °C (dec.) (lit.)

Quality Level

100

Related Categories

Heterocyclic Building Blocks

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Show Differences

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This Item	630721	130877	H31859
Sigma-Aldrich A59654 5-Aminoindole	Sigma-Aldrich 630721 6-Aminoindole	Sigma-Aldrich 130877 5-Aminoindan	Sigma-Aldrich H31859 5-Hydroxyindole
assay 97%	assay 97%	assay 95%	assay 97%
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
form crystals	form solid	form solid	form -
mp 131-133 °C (dec.) (lit.)	mp 75-79 °C	mp 34-36 °C (lit.)	mp 106-108 °C (lit.)

Application

Reactant for preparation of:

Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP
Cytotoxic and antimitotic agents
Insulin-like growth factor 1 receptor inhibitors
Antitumoral agents
Factor Xa inhibitor
Potential antivascular agents
Gli1-mediated transcription in the Hedgehog pathway
Inhibitors of receptor tyrosine kinase with antiangiogenic effects
PKCθ inhibitors
HIV protease inhibitors

pictograms

GHS06,GHS09

signalword

Danger

hcodes

H302,H311,H319,H400

pcodes

P264 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Impaired oxidative phosphorylation regulates necroptosis in human lung epithelial cells.

Michael Jakun Koo et al.

Biochemical and biophysical research communications, 464(3), 875-880 (2015-07-19)

Cellular metabolism can impact cell life or death outcomes. While metabolic dysfunction has been linked to cell death, the mechanisms by which metabolic dysfunction regulates the cell death mode called necroptosis remain unclear. Our study demonstrates that mitochondrial oxidative phosphorylation

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5-Aminoindole