Late Stage Functionalization Toolkit

LSF Toolkit featuring Baran Diversinates, Baran Late-Stage Functionalization Kit

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The Baran Late-Stage Toolkit is a convenient collection of 12 highly innovative reagents that are highly effective in the diversification of complex molecules. The contents in the box are 11 Baran Diversinates and one vial of Palau′Chlor® in amounts of 100 mg each. For obtaining larger amounts of any desired kit component, see the kit component table at the bottom of the page.

Useful Topics:
Late Stage Functionalization

Baran Group – Professor Product Portal


Legal Information

Diversinates is a trademark of Sigma-Aldrich Co. LLC
Palau'Chlor is a registered trademark of Sigma-Aldrich Co. LLC

Kit Components Also Available Separately

Product No.

  • 745480Zinc isopropylsulfinate, 95%

  • 745405Sodium 1,1-difluoroethanesulfinate

  • 745499Zinc trifluoroethanesulfinate

  • 767840Zinc difluoromethanesulfinate, 95%

  • 771406Zinc trifluoromethanesulfinate

  • ALD00288Sodium tert-butylsulfinate

  • ALD00290Sodium 2,2-dimethylpropylsulfinate

  • 792454Palau′Chlor®, 95%

  • 790184Sodium 1-(trifluoromethyl)cyclopropanesulfinate

  • 790796Zinc benzylsulfinate

  • ALD00230Sodium 4,4-difluorocyclohexanesulfinate

  • ALD00232Sodium tetrahydropyransulfinate

See All (12)

Signal Word


Hazard Statements

Target Organs

Respiratory system


NONH for all modes of transport

Certificate of Analysis

Certificate of Origin

A C?H Methylation Reaction of Heteroarenes Inspired by Radical SAM Methyl Transferase.
Gui J, et al.
Journal of the American Chemical Society, 136, 4853-4856 (2014)
Radical C?H Functionalization of Heteroarenes under Electrochemical Control.
O'Brien, et al.
Angewandte Chemie (International Edition in English), 53, 11868-11871 (2014)
Simple Sulfinate Synthesis Enables C-H Trifluoromethylcyclopropanation
Gianatassio R, et al.
Angewandte Chemie (International Edition in English), 53, 9851-9855 (2014)
Palau'chlor: A Practical and Reactive Chlorinating Reagent
Rodriguez RA, et al.
Journal of the American Chemical Society, 136, 6908-6911 (2014)
Yuta Fujiwara et al.
Journal of the American Chemical Society, 134(3), 1494-1497 (2012-01-11)
Molecular scaffolds containing alkylfluorine substituents are desired in many areas of chemical research from materials to pharmaceuticals. Herein, we report the invention of a new reagent (Zn(SO(2)CF(2)H)(2), DFMS) for the innate difluoromethylation of organic substrates via a radical process. This...
Related Content
The Baran Group works with Sigma-Aldrich in providing a portfolio of zinc-based reagents promoting difluoromethylation, trifluoromethylation, trifluoroethylation and isopropylation of aryl and heteroaryl motifs. Baran’s lab has also helped introduce a portable desaturase (Tz0Cl), which promotes the installation of alcohol and amine groups and leaves behind a highly useful tosyl group for further transformations.
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