ALD00444

Sigma-Aldrich

Late Stage Functionalization Toolkit

Synonym(s):
LSF Toolkit featuring Baran Diversinates, Baran Late-Stage Functionalization Kit
NACRES:
NA.22

storage temp.

2-8°C

Related Categories

Application

The Baran Late-Stage Toolkit is a convenient collection of 12 highly innovative reagents that are highly effective in the diversification of complex molecules. The contents in the box are 11 Baran Diversinates and one vial of Palau′Chlor® in amounts of 100 mg each. For obtaining larger amounts of any desired kit component, see the kit component table at the bottom of the page.

Useful Topics:
Late Stage Functionalization

Baran Group – Professor Product Portal

Palau′Chlor
Diversinates

Legal Information

Diversinates is a trademark of Sigma-Aldrich Co. LLC
Palau'Chlor is a registered trademark of Sigma-Aldrich Co. LLC

Kit Components Also Available Separately

Product No.
Description
SDS

  • 745480Zinc isopropylsulfinate, 95%

  • 745405Sodium 1,1-difluoroethanesulfinate

  • 745499Zinc trifluoroethanesulfinate

  • 767840Zinc difluoromethanesulfinate, 95%

  • 771406Zinc trifluoromethanesulfinate

  • ALD00288Sodium tert-butylsulfinate

  • ALD00290Sodium 2,2-dimethylpropylsulfinate

  • 792454Palau′Chlor®, 95%

  • 790184Sodium 1-(trifluoromethyl)cyclopropanesulfinate

  • 790796Zinc benzylsulfinate

  • ALD00230Sodium 4,4-difluorocyclohexanesulfinate

  • ALD00232Sodium tetrahydropyransulfinate

See All (12)

Signal Word

Danger

Hazard Statements

Target Organs

Respiratory system

RIDADR

NONH for all modes of transport

Certificate of Analysis

Certificate of Origin

A C?H Methylation Reaction of Heteroarenes Inspired by Radical SAM Methyl Transferase.
Gui J, et al.
Journal of the American Chemical Society, 136, 4853-4856 (2014)
Radical C?H Functionalization of Heteroarenes under Electrochemical Control.
O'Brien, et al.
Angewandte Chemie (International Edition in English), 53, 11868-11871 (2014)
Simple Sulfinate Synthesis Enables C-H Trifluoromethylcyclopropanation
Gianatassio R, et al.
Angewandte Chemie (International Edition in English), 53, 9851-9855 (2014)
Palau'chlor: A Practical and Reactive Chlorinating Reagent
Rodriguez RA, et al.
Journal of the American Chemical Society, 136, 6908-6911 (2014)
Yuta Fujiwara et al.
Journal of the American Chemical Society, 134(3), 1494-1497 (2012-01-11)
Molecular scaffolds containing alkylfluorine substituents are desired in many areas of chemical research from materials to pharmaceuticals. Herein, we report the invention of a new reagent (Zn(SO(2)CF(2)H)(2), DFMS) for the innate difluoromethylation of organic substrates via a radical process. This...
Related Content
The Baran Group works with Sigma-Aldrich in providing a portfolio of zinc-based reagents promoting difluoromethylation, trifluoromethylation, trifluoroethylation and isopropylation of aryl and heteroaryl motifs. Baran’s lab has also helped introduce a portable desaturase (Tz0Cl), which promotes the installation of alcohol and amine groups and leaves behind a highly useful tosyl group for further transformations.
Read More

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

MilliporeSigma

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.