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ALD00598

Sigma-Aldrich

CITU

≥95%

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Synonym(s):
1,1,3,3-Tetramethyl-2-(4,5,6,7-tetrachloro-1,3-dioxoisoindolin-2-yl)isouronium
hexafluorophosphate(V)
Empirical Formula (Hill Notation):
C13H12Cl4F6N3O3P
CAS Number:
Molecular Weight:
545.03

Quality Level

Assay

≥95%

form

powder

reaction suitability

reaction type: Coupling Reactions

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This Item
8.510138.51012660272
CITU ≥95%

Sigma-Aldrich

ALD00598

CITU

HATU Novabiochem®

Sigma-Aldrich

8.51013

HATU

HCTU O-(1H-6-Chlorobenzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate Novabiochem®

Sigma-Aldrich

8.51012

HCTU

CX12 Umicore

Sigma-Aldrich

660272

CX12

form

powder

form

solid

form

powder

form

solid

reaction suitability

reaction type: Coupling Reactions

reaction suitability

reaction type: Coupling Reactions

reaction suitability

reaction type: Coupling Reactions

reaction suitability

-

Quality Level

100

Quality Level

300

Quality Level

300

Quality Level

100

General description

CITU is an efficient coupling reagent used in solid and solution phase peptide synthesis, particularly, in acylation and decarboxylative cross-coupling reactions. It can also be used as an activator in the Ni-catalyzed Negishi arylation, alkenylation, alkylation, and alkynylation reactions.

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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CITU: a peptide and decarboxylative coupling reagent
deGruyter JN, et al.
Organic Letters, 19(22), 6196-6199 (2017)

Articles

Novabiochem® offers a large number of coupling reagents for in situ activation. In situ activating reagents are easy to use, fast reacting – even with sterically hindered amino acids, and their use is generally free of side reactions.

Related Content

The Baran Group works with Sigma-Aldrich in providing a portfolio of zinc-based reagents promoting difluoromethylation, trifluoromethylation, trifluoroethylation and isopropylation of aryl and heteroaryl motifs. Baran’s lab has also helped introduce a portable desaturase (Tz0Cl), which promotes the installation of alcohol and amine groups and leaves behind a highly useful tosyl group for further transformations.

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