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MilliporeSigma

B1253

Butylated hydroxyanisole

≥98.5%

Synonym(s):

2(3)-t-Butyl-4-hydroxyanisole, 2(3)-t-Butylhydroquinone monomethyl ether, BHA

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5 G

$31.40

100 G

$45.90

500 G

$137.00

$31.40


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About This Item

Linear Formula:
(CH3)3CC6H3(OCH3)OH
CAS Number:
Molecular Weight:
180.24
UNSPSC Code:
12352100
NACRES:
NA.22
EC Number:
246-563-8
MDL number:

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Product Name

Butylated hydroxyanisole, ≥98.5%

SMILES string

O(C)c1cc(c(cc1)O)C(C)(C)C

InChI key

MRBKEAMVRSLQPH-UHFFFAOYSA-N

InChI

1S/C11H16O2/c1-11(2,3)9-7-8(13-4)5-6-10(9)12/h5-7,12H,1-4H3

vapor density

6.2 (vs air)

assay

≥98.5%

form

powder

autoignition temp.

599 °F

mp

58-60 °C (lit.)

Quality Level

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1 of 4

This Item
78943W21830849886
assay

≥98.5%

assay

≥99.0% (sum of isomers, GC)

assay

99%

assay

-

Quality Level

200

Quality Level

100

Quality Level

400

Quality Level

300

form

powder

form

-

form

-

form

-

mp

58-60 °C (lit.)

mp

58-60 °C (lit.)

mp

58-60 °C (lit.)

mp

58-60 °C (lit.)

vapor density

6.2 (vs air)

vapor density

6.2 (vs air)

vapor density

6.2 (vs air)

vapor density

6.2 (vs air)

autoignition temp.

599 °F

autoignition temp.

599 °F

autoignition temp.

599 °F

autoignition temp.

599 °F

Application

  • Antioxidant peptides from silk protein: Research explores the purification of novel antioxidant peptides derived from Bombyx mori pupae, identifying potential antioxidant applications for butylated hydroxyanisole in the food and cosmetic industries (Chukiatsiri et al., 2024).
  • Industrial lubricant additive: The performance of olive oil-based blended esters with butylated hydroxyanisole is evaluated, showcasing its efficacy as an industrial lubricant additive and its optimization using response surface methodology (Thangaraj et al., 2024).
  • Environmental degradation studies: Investigates the degradation of butylated hydroxyanisole using advanced oxidation processes, providing insights into environmental safety and the compound′s stability in pharmaceutical and industrial applications (Shi et al., 2024).

General description

Butylated hydroxyanisole is mainly used as a synthetic antioxidant in food and cosmetics. It is being extensively studied for potential toxicity.[1][2]

Other Notes

Mixed isomers (minimum 90% 3-isomer/9% 2-isomer)

pictograms

Environment

hcodes

Hazard Classifications

Aquatic Chronic 2

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

241.9 °F - Pensky-Martens closed cup

flash_point_c

116.6 °C - Pensky-Martens closed cup

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


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Cytotoxicity of butylated hydroxyanisole and butylated hydroxytoluene in isolated rat hepatocytes
Thompson, David and Moldeus, Peter
Biochemical Pharmacology, 37(11), 2201-2207 (1988)
Stefanie D Roth et al.
PloS one, 7(9), e44505-e44505 (2012-09-14)
Inefficient intracellular protein trafficking is a critical issue in the pathogenesis of a variety of diseases and in recombinant protein production. Here we investigated the trafficking of factor VIII (FVIII), which is affected in the coagulation disorder hemophilia A. We
Toxicology and biochemistry of butylated hydroxyanisole and butylated hydroxytoluene.
A L Branen
Journal of the American Oil Chemists' Society, 52(2), 59-63 (1975-02-01)
Bhupendra Singh et al.
Carcinogenesis, 33(12), 2601-2610 (2012-10-03)
Epidemiological data and studies in rodent models strongly support the role of estrogens in the development of breast cancers. Oxidative stress has been implicated in this carcinogenic process. We have recently demonstrated that antioxidants vitamin C or butylated hydroxyanisole (BHA)
Bhupendra Singh et al.
Carcinogenesis, 33(1), 156-163 (2011-11-11)
Exact mechanisms underlying the initiation and progression of estrogen-related cancers are not clear. Literature, evidence and our studies strongly support the role of estrogen metabolism-mediated oxidative stress in estrogen-induced breast carcinogenesis. We have recently demonstrated that antioxidants vitamin C and

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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