This product is intended for research use only and is not suitable for human or animal consumption. The currently offered package sizes are 250mg, 1g, and 5g.
C3878
Chlorogenic acid
≥95% (titration)
Synonym(s):
CGA, 1,4,5-Trihydroxycyclohexanecarboxylic acid 3-(3,4-dihydroxycinnamate), 3-(3,4-Dihydroxycinnamoyl)quinic acid
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250 MG
$42.50
1 G
$137.00
5 G
$357.00
About This Item
Empirical Formula (Hill Notation):
C16H18O9
CAS Number:
Molecular Weight:
354.31
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
206-325-6
MDL number:
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InChI key
CWVRJTMFETXNAD-JUHZACGLSA-N
InChI
1S/C16H18O9/c17-9-3-1-8(5-10(9)18)2-4-13(20)25-12-7-16(24,15(22)23)6-11(19)14(12)21/h1-5,11-12,14,17-19,21,24H,6-7H2,(H,22,23)/b4-2+/t11-,12-,14-,16+/m1/s1
SMILES string
O[C@@H]1C[C@](O)(C[C@@H](OC(=O)\C=C\c2ccc(O)c(O)c2)[C@@H]1O)C(O)=O
assay
≥95% (titration)
form
powder
mp
210 °C (dec.) (lit.)
Quality Level
Gene Information
rat ... G6pc(25634)
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This Item | |||
|---|---|---|---|
| assay ≥95% (titration) | assay - | assay ≥95.0% (HPLC) | assay - |
| form powder | form - | form solid | form - |
| Quality Level 200 | Quality Level - | Quality Level - | Quality Level - |
| mp 210 °C (dec.) (lit.) | mp 210 °C (dec.) (lit.) | mp 210 °C (dec.) (lit.) | mp 210 °C (dec.) (lit.) |
| Gene Information rat ... G6pc(25634) | Gene Information - | Gene Information - | Gene Information - |
General description
Chlorogenic acid is a bioactive polyphenolic compound mainly found in many plants[1], such as coffee.[2] It is a potent neuroprotectant[3] and also possesses antiviral[1], antifungal[3], antioxidant[2] and antitumor properties.[4] CGA may also be involved in regulating glucose and lipid metabolism and improving insulin sensitivity.[5]
Chlorogenic acid is a cinnamate ester used as a reducing agent and stabilizer in bimetallic nanoparticle synthesis.[6]
Application
- Antioxidant and Phenolic Profiles: A study detailed the antioxidant and phenolic profiles of Thai medicinal plants, including chlorogenic acid, to support functional food and pharmaceutical development, highlighting its potential applications in enhancing food functionality and health benefits (Wanyo et al., 2024).
- Intravesical Therapy for Cystitis: Research demonstrated the use of chlorogenic acid in intravesical therapy to modify acute voiding behavior in mice with systemic lipopolysaccharide inflammation-induced cystitis, suggesting therapeutic potential in bladder disorders (Yeh et al., 2024).
- Cardioprotection in Chemotherapy: A hydroethanolic extract containing chlorogenic acid was investigated for its role in mitigating doxorubicin-induced cardiotoxicity through mitochondrial protection mediated by AMPK-PGC-1α-SOD, underscoring its potential in protective strategies against chemotherapy-induced cardiac damage (Song et al., 2024).
- Nutritional Delivery and Food Industry: A review discussed chlorogenic acid′s role in nutrition delivery and its implications in the food industry, proposing its use as nanoparticles for active food packaging application. (Hu et al., 2024).
Disclaimer
May yield a hazy solution in ethanol
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Chlorogenic acid and coffee prevent hypoxia-induced retinal degeneration
Jang H
Journal of Agricultural and Food Chemistry, 62(1), 182-191 (2013)
Roles of chlorogenic acid on regulating glucose and lipids metabolism: a review
Meng S
Evidence-Based Complementary and Alternative Medicine : ECAM (2013)
Controlled green synthesis of Au-Pt bimetallic nanoparticles using chlorogenic acid
Chen R, et al.
Research on Chemical Intermediates, 47, 4051-4066 (2021)
Chlorogenic acid and caffeic acid are absorbed in humans
Olthof MR
The Journal of Nutrition, 131(1), 66-71 (2001)
Shp2 regulates chlorogenic acid-induced proliferation and adipogenic differentiation of bone marrow-derived mesenchymal stem cells in adipogenesis
Zhou RP
Molecular Medicine Reports, 11(6), 4489-4495 (2015)
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What is the recommended serving amount of chlorigenic acid in the product, and how many servings are in each bottle?
1 answer-
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1) What are the storage conditions for this product? 2)What is the solubility in DMSO? 3) What are the storage conditions once dissolved in DMSO?
1 answer-
This product, in powder form, should be stored refrigerated at 2-8°C. The solubility of this material is tested in ethanol at 25 mg/mL. The solubility in DMSO has not been investigated. Various sources indicate rates in DMSO ranging from 10 - 70 mg/mL with higher rates resulting from the use of dry or anhydrous solvent. Stock solutions prepared in DMSO may be stored in aliquots at -20°C for up to 1 year.
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Is this a synthetic product or is it isolated from natural sources?
1 answer-
This product is isolated from natural sources. Please see the link below to review a sample Certificate of Origin:
https://www.sigmaaldrich.com/coo/undefined/C3878/*Helpful?
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