C80105

Chrysin

Name: Chrysin
Brand: ALDRICH
Price: 172 USD

≥96.5% purity, powder

Synonym(s):

5,7-Dihydroxyflavone

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25 G

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₀O₄

CAS Number:

480-40-0

Molecular Weight:

254.24

Beilstein/REAXYS Number:

233276

EC Number:

207-549-7

MDL number:

MFCD00006834

UNSPSC Code:

12171500

PubChem Substance ID:

24893009

NACRES:

NA.47

Key Documents

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Product Name

Chrysin, ≥96.5%

Quality Level

100

assay

≥96.5%

form

powder

color

beige

mp

284-286 °C (lit.)

solubility

0.1 M NaOH: 0.008 g/L

λ_max

348 nm

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

Oc1cc(O)c2C(=O)C=C(Oc2c1)c3ccccc3

InChI

1S/C15H10O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-8,16-17H

InChI key

RTIXKCRFFJGDFG-UHFFFAOYSA-N

Gene Information

human ... CDC2(983), CDK5(1020), CDK6(1021), CYP19A1(1588), CYP1A2(1544), GSK3A(2931)
mouse ... Hexa(15211), Ptgs2(19225)
rat ... Gabra2(29706)

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Clinical & Diagnostics

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Show Differences

1 of 4

This Item	95082	PHL85724	429031
Sigma-Aldrich C80105 Chrysin	Supelco 95082 Chrysin	PHL85724 Chrysin 7-glucuronide	Sigma-Aldrich 429031 4,7-Dihydroxy-1,10-phenanthroline
color beige	color -	color -	color -
solubility 0.1 M NaOH: 0.008 g/L	solubility -	solubility -	solubility -
form powder	form -	form solid	form powder or chunks
application(s) diagnostic assay manufacturing hematology histology	application(s) food and beverages	application(s) -	application(s) diagnostic assay manufacturing hematology histology
Quality Level 100	Quality Level 100	Quality Level -	Quality Level 100
storage temp. room temp	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. room temp

Application

Chrysin has been used to study the effect of bioflavonoids on the inhibition of ATP synthase in Escherichia coli.[1]
It has been used to study the effect of Chrysin on eIF4E (eukaryotic translation initiation factor 4E) expression in AGS cell (human gastric carcinoma cell) line.[2]
It has been used to study the effect of chrysin on human ovarian cancer cells.[3]

Biochem/physiol Actions

Chrysin is a flavonoid and an analog of apigenin. It inhibits aromatase and also suppresses human immunodeficiency virus (HIV) activation in models with latent infection. Chrysin exhibits anti-inflammatory and anti-oxidant effects. This molecule induces apoptosis in various cells, thereby exhibiting cancer chemopreventive activity.[4] Chrysin can modulate the activity of GABAA (Type-A γ-aminobutyric acid) and GABAC receptors, it downregulates expression of PCNA (proliferating cell nuclear antigen), reduces activity of CDK2 (cyclin-dependent kinase 2) and CDK4 and induces p38-MAPK (mitogen-activated protein kinase) activation.[5]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Cytotoxic and Pro-Apoptotic Effects of Honey Bee Venom and Chrysin on Human Ovarian Cancer Cells.

Amini E, et al.

Asia Pacific Journal of Medical Toxicology, 4 (2015)

Inhibition of aromatase activity by flavonoids.

H J Jeong et al.

Archives of pharmacal research, 22(3), 309-312 (1999-07-14)

In searching for potent cancer chemopreventive agents from synthetic or natural products, 28 randomly selected flavonoids were screened for inhibitory effects against partially purified aromatase prepared from human placenta. Over 50% of the flavonoids significantly inhibited aromatase activity, with greatest

Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing p21Waf1/Cip1 expression: involvement of p38 mitogen-activated protein kinase.

Weng MS, et al.

Biochemical Pharmacology, 69, 1815-1815 (2005)

Protection by chrysin, apigenin, and luteolin against oxidative stress is mediated by the Nrf2-dependent up-regulation of heme oxygenase 1 and glutamate cysteine ligase in rat primary hepatocytes.

Chin-Shiu Huang et al.

Archives of toxicology, 87(1), 167-178 (2012-08-07)

Chrysin, apigenin, and luteolin are flavones that differ in their number of hydroxyl groups in the B ring. In this study, we investigated the protection by chrysin, apigenin, and luteolin against tert-butyl hydroperoxide (tBHP)-induced oxidative stress and the possible mechanisms

Effects of in ovo injection of chrysin, quercetin and ascorbic acid on hatchability, somatic attributes, hepatic oxidative status and early post-hatch performance of broiler chicks.

F Khaligh et al.

Journal of animal physiology and animal nutrition, 102(1), e413-e420 (2017-06-22)

An experiment was conducted to evaluate the effects of in ovo injection of chrysin, quercetin and ascorbic acid on hatchability, somatic attributes, hepatic antioxidant status and early post-hatch growth performance of broiler chicks. Four hundred and eighty embryonated broiler breeder

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