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CDS021620

Sigma-Aldrich

Fasudil hydrochloride

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Empirical Formula (Hill Notation):
C14H18ClN3O2S
Molecular Weight:
327.83
MDL number:
PubChem Substance ID:

description

AldrichCPR

form

solid

SMILES string

[H]Cl.O=S(C1=CC=CC2=C1C=CN=C2)(N3CCCNCC3)=O

InChI

1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H

InChI key

LFVPBERIVUNMGV-UHFFFAOYSA-N

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description

AldrichCPR

description

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description

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description

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General description

Fasudil hydrochloride is an intracellular calcium channel blocker. It is also a potent vasodilator agent, antihypertensive agent, and protein kinase inhibitor.

Other Notes

Please note that Sigma-Aldrich provides this product to early discovery researchers as part of a collection of unique chemicals. Sigma-Aldrich does not collect analytical data for this product. Buyer assumes responsibility to confirm product identity and/or purity. All sales are final.
NOTWITHSTANDING ANY CONTRARY PROVISION CONTAINED IN SIGMA-ALDRICH′S STANDARD TERMS AND CONDITIONS OF SALE OR AN AGREEMENT BETWEEN SIGMA-ALDRICH AND BUYER, SIGMA-ALDRICH SELLS THIS PRODUCT "AS-IS" AND MAKES NO REPRESENTATION OR WARRANTY WHATSOEVER WITH RESPECT TO THIS PRODUCT, INCLUDING ANY (A) WARRANTY OF MERCHANTABILITY, (B) WARRANTY OF FITNESS FOR A PARTICULAR PURPOSE, OR (C) WARRANTY AGAINST INFRINGEMENT OF INTELLECTUAL PROPERTY RIGHTS OF A THIRD PARTY, WHETHER ARISING BY LAW, COURSE OF DEALING, COURSE OF PERFORMANCE, USAGE OF TRADE OR OTHERWISE.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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S Nakashima et al.
Neurologia medico-chirurgica, 38(12), 805-810 (1999-03-04)
Fasudil hydrochloride is a new type of intracellular calcium antagonist, different from the calcium entry blockers that are commonly employed for clinical use. Since September 1995, the combination of fasudil hydrochloride and ozagrel sodium, an inhibitor of thromboxane A2 synthesis
Intracranial hemorrhage after intra-arterial administration of fasudil for treatment of cerebral vasospasm following subarachnoid hemorrhage: a serious adverse event.
Masahiro Ishihara et al.
Neuroradiology, 54(1), 73-75 (2011-03-25)
Y Hou et al.
Neuroscience, 200, 120-129 (2011-11-09)
Fasudil hydrochloride (FH), a Rho kinase inhibitor, is used to treat neurological diseases. This study aims to elucidate the anti-dementia role of FH in Alzheimer's disease. Twenty-four Sprague-Dawley rats were randomly divided into four groups: (1) sham-operated group (control), (2)
Tian-Yi Yuan et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 109, 1867-1875 (2018-12-16)
Hypertension crisis is a severe disease and needs emergency treatment in clinic. It is an important task to discover novel drugs which could lower the blood pressure steadily and quickly. However, animal models for screening anti-hypertensive crisis agents are unsatisfactory.

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